Contacto
Campos de conocimiento
Biofísica
Biología del Desarrollo
Líneas de investigación
Regulación del desarrollo, la plasticidad y el funcionamiento de las células beta pancreáticas.
Mecanismos de desarrollo desecreción de insulina, resistencia a la insulina y obesidad.
Publicaciones
- Garcia-Delgado N, Velasco M, Sanchez-Soto C, Manlio Diaz-Garcia C e Hiriart M 2018 Calcium
channels in postnatal development of rat pancreatic beta cells and their role in insulin secretion. Frontiers in Endocrinology (Lausanne) 5; 9:40, doi: 10.3389/fendo.2018.00040
- Ortíz-Rentería M, Juárez-Contreras R, González-Ramírez R, Islas LD, Sierra-Ramírez F, Llorente I, Simon SA, Hiriart M, Rosenbaum T, Morales-Lázaro SL. 2018 TRPV1 channels and the progesterone receptor Sig-1R interact to regulate pain. Proc Natl Acad Sci U S A. doi: 10.1073/pnas.1715972115. PMID: 29378958
- Velasco, M., Larqué, C., Díaz-García, C.M., Sanchez-Soto, C., Hiriart, M 2018 Rat pancreatic beta-cell culture. Methods in Molecular Biology 172: 26
- Carbajal-Ramírez A, García-Macedo R, Díaz-García CM, Sanchez-Soto C, Padrón AM, de la Peña JE, Cruz M, Hiriart M. 2017 Neuropathy-specific alterations in a Mexican population of diabetic patients. BMC Neurol 17:161 doi: 10.1186/s12883-017-0939-6. PMID: 28841856
- Rodriguez-Sosa M, Cabellos-Avelar T, Sanchez-Zamora Y, Juárez-Avelar I, García-Reyes E, Lira-León A, Benítez-Flores JDC, Pacheco-Fernández T, Hiriart M, Gutiérrez-Cirlos EB. 2017 Proinflammatory cytokine MIF plays a role in the pathogenesis of type-2 diabetes mellitus, but does not affect hepatic mitochondrial function. Cytokine pii: S1043-4666(17)30210-7. doi: 10.1016/j.cyto.2017.07.012.
- Martinez-Sanchez ME, Hiriart M, Alvarez-Buylla ER. 2017 The CD4+ T cell regulatory network mediates inflammatory responses during acute hyperinsulinemia: a simulation study. BMC Syst Biol. 11(1): 64. doi: 10.1186/s12918-017-0436-y.
- Rebolledo-Solleiro D, Roldán-Roldán G, Díaz D, Velasco M, Larqué C, Rico-Rosillo G, Vega-Robledo GB, Zambrano E, Hiriart M, Pérez de la Mora M. 2017 Increased anxiety-like behavior is associated with the metabolic syndrome in non-stressed rats. PLoS One 12(5): e0176554. doi: 10.1371/journal.pone.0176554. PMID: 28463967.
- Torres-Villalobos G. Hamdan-Pérez N, Díaz-Villaseñor A, Tovar A, Torre-Villalvazo I, Ordaz-Nava G, Morán-Ramos S, Noriega L, Martínez-Benítez B, López-Garibay A, Torres-Landa S, Ceballos-Cantú J, Tovar-Palacio C, Figueroa-Juárez E, Hiriart M, Medina-Santillán R, Castillo-Hernández MC, Torres N 2016 Autologous subcutaneous adipose tissue transplants improve adipose tissue metabolism and reduce insulin resistance and fatty liver in diet-induced obesity rats. Physiol Rep. 4(17) pii: e12909. doi: 10.14814/phy2.12909.
- Sánchez-Zamora YI, Juárez-Avelar I, Vázquez-Mendoza A, Hiriart M, Rodríguez-Sosa M J 2016. Altered Macrophage and Dendritic Cell Response in Mif−/− Mice Reveals a Role of Mif for Inflammatory-Th1 Response in Type 1 Diabetes J Diabetes Res. 2016:7053963.
-Velasco M, Diaz-Garcia CM, Larque C, Hiriart M. 2016 Modulation of ionic channels and insulin secretion by drugs and hormones in pancreatic beta cells. Mol Pharmacol. 90(3):341-57. doi: 10.1124/mol.116.103861.
- Salinas RM, Hiriart M, Acosta I, Sosa AL, Prince MJ 2016 Type 2 diabetes mellitus as a risk factor for dementia in a Mexican population. J Diabetes Complications 30(7):1234-9. doi: 10.1016/j.jdiacomp.2016.06.005.
- Larqué CA, Velasco Torres M, Barajas F, García-Delgado N, Chávez-Maldonado JP, García-Morales J, Orozco L, Hiriart M. 2016 Transcriptome landmarks of the functional maturity of rat beta cells, from lactation to adulthood. J Mol Endocrinol 57(1):45-59. doi: 10.1530/JME-16-0052.
- Torres-Villalobos G, Hamdan-Pérez N, Tovar AR, Ordaz-Nava G, Martínez-Benítez B, Torre-Villalvazo I, Morán-Ramos S, Díaz-Villaseñor A, Noriega LG, Hiriart M, Medina-Santillán R, Carmen Castillo-Hernandez MD, Méndez-Sánchez N, Uribe M, Torres N. 2015 Combined high-fat diet and sustained high sucrose consumption promotes NAFLD in a murine model. Ann Hepatol. 2015; 14(4):540-546.
- Hiriart M, Velasco M, Díaz -García CM, Larqué C, Sánchez-Soto C, Albarado-Ibáñez A, Chávez-Maldonado JP, Toledo A, García-Delgado N. Pancreatic beta cells in metabolic syndrome. 2014 En The Islets of Langerhans, 2nd Edition, Md S Islam. (Ed.), Springer. Advances in Experimental Medicine and Biology 654, 30: 817-844.
- Hiriart M, Sanchez-Soto C, Diaz-Garcia CM, Castanares DT, Avitia M, Velasco M, Mas-Oliva J, Macias-Silva M, González-Villalpando C, Delgado-Coello B, Sosa-Garrocho M, Vidaltamayo R, Fuentes-Silva D. 2014 Hyperinsulinemia is associated with increased soluble insulin receptors release from hepatocytes. Front Endocrinol (Lausanne) 19; 5:95. doi: 10.3389/fendo.2014.00095.
- Díaz-Garcia CM, Morales-Lázaro S, Sanchez-Soto C, Velasco M, Rosenbaum T, Hiriart M 2014 Role for the TRPV1 channel in insulin secretion from pancreatic beta-cells. J Memb Biol, 247 (6): 479-491.
- Hiriart M, Velasco M, Larqué C, Díaz-García CM. Metabolic syndrome and ionic channels in pancreatic beta-cells. (2014) Vitamins and Hormones 95: 87-114. doi: 10.1016/B978-0-12-800174-5.00004-1. PMID: 24559915
- Romo-Yáñez J, Velasco M, Larqué C, Chávez-Maldonado JP, Hiriart M. (2014) Differential expression of NGF and BDNF in rat adipose depots during early development and adulthood. Adipobiology 5: ISSN 1313-3705. 5: 39-43.
- Albarado-Ibañez A, Avelino-Cruz J E, Velasco M, Torres-Jácome J, Hiriart M (2013) Metabolic syndrome remodels electrical activity of the sinoatrial node and produces arrhythmias in rats. 2013 Plos One 8; 8(11):e76534. doi: 10.1371/journal.pone.0076534.
- Rebolledo-Solleiro D, Crespo-Ramírez M, Roldán-Roldán G, Hiriart M, Pérez de la Mora M (2013) Role of thirst and visual barriers in the differential behavior displayed by streptozotocin-treated rats in the elevated plus-maze and the open field test. Physiol and Behavior 120: 130-135.
- Díaz-Villaseñor A, Cruz L, Cebrián A, Hernández-Ramírez RU, Hiriart M, García-Vargas G, Bassol S, Sordo M, Gandolfi AJ, Klimecki WT, López-Carillo L, Cebrián ME, Ostrosky-Wegman P (2013) Arsenic exposure and calpain-10 polymorphisms impair the function of pancreatic beta-cells in humans: A Pilot Study of Risk Factors for T2DM. PLoS One 8(1):e51642 doi: 10.1371/journal.pone.0051642. PMID: 23349674.
- Díaz-García CM, Sanchez-Soto C, Hiriart M. (2013) TRPM channels phosphorylation as a potential bridge between old signals and novel regulatory mechanisms of insulin secretion. Curr Diabetes Rev 1; 9 (2):117-25.
- Velasco M, Larqué C, Gutiérrez-Reyes G, Arredondo R, Sánchez-Soto C, Hiriart M. (2012) Metabolic syndrome induces changes in KATP-channels and calcium currents in pancreatic β-cells. Islets 4(4):302-11, doi: 10.4161/isl.21374, PMID: 22885660.
- Diaz-Garcia CM, Fuentes-Silva D, Sanchez-Soto C, Domínguez-Pérez D, García-Delgado N, Varela C, Mendoza-Hernández G, Rodriguez-Romero A, Castaneda O, Hiriart M. (2012) Toxins from Physalia physalis (Cnidaria) raise the intracellular Ca2+ of beta-cells and promote insulin secretion. Curr Med Chem. 19(31):5414-23 PMID: 22830340.
- Díaz-García CM, Sánchez-Soto C, Fuentes-Silva D, Leon-Pinzon C, Domínguez Pérez D, Varela C, Rodriguez-Romero A, Castañeda O, Hiriart M (2012) Low molecular weight compounds from Zoanthus sociatus impair insulin secretion via Ca+2 influx blockade and cause glucose intolerance in vivo. Toxicon 59(2):306-314.
