Duplicacion génica y evolución.
Diversificación funcional de genes parálogos.
Analisis de la función y regulación de genes tipo ancestral en comparación con los ortólogos de S. cerevisiae.
Cambios en la regulación de la expresión, localización subcelular y en las propiedades cinéticas de los productos de genes ortólogos de S. cerevisiae y de levaduras tipo ancestral (S. kluyveri, y K. lactis).

Publicaciones

1. López, G., H. Quezada, Duhne, M., González, J., Lezama, M., Mohamed, E., Colón, M., Martínez de la Escalera, X., Flores-Villegas, M., Scazzocchio, C., DeLuna, A., González, A. Biochemical Diversification of Paralogous α-Isopropylmalate Synthases by Modulation of Feedback Control Sensitivity and Protein Oligomerization in the Yeast Saccharomyces cerevisiae Eukaryotic Cell 14: 564-577 (2015). IF: 2.992

2. Montalvo-Arredondo, J1., Jimenez-Benitez, A1., Colón-González, M2., González-Flores, J2., Flores-Villegas, M2., González, A2., Riego-Ruiz L1+. Functional roles of a predicted branched chain amino transferase encoded by the LkBAT1 gene of the yeast Lachancea kluyveri Fungal Genetics and Biology. 2015 Dec;85:71-82. doi: 10.1016/j.fgb.2015.11.004. Epub 2015 Nov 10. IF: 3.072

3. De Angelis L, Rinaldi T, Cirigliano A, Bello C, Reverberi M, Amaretti A, Montanari A, Santomartino R, Raimondi S, Gonzalez A, Bianchi MM. Functional roles of the fatty acid desaturases encoded by KlOLE1, FAD2 and FAD3 in the yeast Kluyveromyces lactis. Microbiology. 2016 May 27. doi: 10.1099/mic.0.000315. [Epub ahead of print] IF: 0.856

4. Campero-Basaldúa, C., Quezada, H., Riego-Ruiz, L., Márquez, D., Rojas, E., González, J., El-Hafidi, M., González, A. Diversification of the kinetic properties of yeast NADP-glutamate-dehydrogenase isozymes procedes independently of their evolutionary origin. MicrobiologyOpen 2016; 1-18 DOI: 10.1002/mbo3.419. IF: 2.747

5. Escalera-Fanjul X., Campero-Basaldúa C., Colón, M., González, J.,Márquez, D., González,A. Evolutionary Diversification of Alanine Transaminases in Yeast: Catabolic Specialization and Biosynthetic Redundancy . Frontiers in Microbiology. 26 de Junio 2017. Doi:10.3389/fmicb.2017.01150 IF: 4.076

6. González J, Geovani López, Stefany Argueta, Ximena Escalera-Fanjul, Mohamed el Hafidi, Carlos Campero-Basaldua, Joseph Strauss, Lina Riego-Ruiz and Alicia González. 2017. Diversification of Transcriptional Regulation Determines Subfunctionalization of Paralogous Branched Chain Aminotransferases in the Yeast Saccharomyces cerevisiae. Genetics. DOI: 10.1534/genetics.117.300290 II: 4.556

7. Erendira Rojas-O rtega, Beatriz Aguirre, Horacio Reyes-Vivas, Martín GonzálezAndrade, Jose Carlos Campero-Basaldúa, Juan Pablo Pardo, and Alicia González. 2018 Saccharomyces cerevisiae Differential Functionalization of Presumed ScALTl and ScALT2 Alanine Transaminases has Been Driven by Diversification of Pyridoxal Phosphate Interactions. Frontiers in Microbiology. DOI 10.3389/fmicb.2018.00944 IF: 4.076

Circuito de Posgrado, Ciudad Universitaria
Alcaldía Coyoacán, C.P. 04510, México, CDMX

55 5623 7006
mdcbq@posgrado.unam.mx