Acceso a usuarios
Bienvenid@

Tutores

CLARA ESPITIA PINZON

Instituto de Investigaciones Biomédicas (IIB)

Contacto

Teléfono: 55 5556223860 Ext. 23860
Email: espitia@iibiomedicas.unam.mx
Sitio web: Visitar sitio web

Campos de conocimiento

Microbiología Molecular

Líneas de investigación

Caracterización genética, funcional e inmunológica de los antígenos de Mycobacterium tuberculosis involucrados en la interacción hospedero-bacteria

Publicaciones

-Guzmán-Gutiérrez SL, Nieto-Camacho A, Castillo-Arellano JI, Huerta-Salazar E, Hernández-Pasteur G, Silva-Miranda M, Argüello-Nájera O, Sepúlveda-Robles O, Espitia CI* and Reyes-Chilpa R* Mexican Propolis: A Source of Antioxidants and Anti-Inflammatory Compounds, and Isolation of a Novel Chalcone and Caprolactone Derivative. Molecules. 2018, 6:23(2)
-Ayón-Núñez DA, Fragoso G, Espitia C, García-Varela M, Soberón X , Rosas G , Laclettea J P. Bobes R J, Identification and characterization of Taenia solium enolase as a plasminogen-binding protein. Acta Trop. 2018, 18:182:69-79.
-Trenado-Uribe M, Silva-Miranda M, Rivero-Cruz JF, Rodríguez-Peña K, Espitia-Pinzón CI, Rodríguez-Sanoja R, Sánchez S. Antimycobacterial activity of an anthracycline produced by an endophyte isolated from Amphipterygium adstringens. Mol Biol Rep. 2018, 45:2563-2570.
- Alonso-Castro AJ, Guzmán-Gutiérrez SL, Betancourt CA, Gasca-Martínez D, Álvarez-Martínez KL, Pérez-Nicolás M, Espitia-Pinzón CI, Reyes-Chilpa R. Anticonceptive, anti-inflammatory, and central nervous system (CNS) effects of the natural coumarin soulatrolide. Drug Dev Res. 2018, 79:332-338.
-Sepúlveda-Robles O, Espinoza-Gutiérrez B, Gomez-Verjan JC, Guzmán-Gutiérrez SL, De Ita M, Silva-Miranda M, Espitia-Pinzón CI, Fernández-Ramírez F, Herrera-Salazar A, Mata-Rocha M, Ortega-Hernández A, Reyes-Chilpa R. Trypanocidal and toxicological assessment in vitro and in silico of three sesquiterpene lactones from Asteraceae plant species. Food Chem Toxicol. 2019, 125:55-61.
-Ortega-Vargas S, Espitia C, Sahagún-Ruiz A, Parada C, Balderas-Loaeza A, Villa-Mancera A, Quiroz-Romero H. Moderate protection is induced by a chimeric protein composed of leucine aminopeptidase and cathepsin L1 against Fasciola hepatica challenge in sheep. 2019, 27:3234-3240. Vaccine...
-Bando-Campos G, Juárez-López D, Román-González SA, Castillo-Rodal AI, Olvera C, López-Vidal Y, Arreguín-Espinosa R, Espitia C, Trujillo-Roldán MA, Valdez-Cruz NA. Recombinant O-mannosylated protein production (PstS-1) from Mycobacterium tuberculosis in Pichia pastoris (Komagataella phaffii) as a tool to study tuberculosis infection. Microb Cell Fact. 2019, 18.
-Aguilar-López BA, Correa F, Moreno-Altamirano MMB, Espitia C, Hernández-Longoria R, Oliva-Ramírez J, Padierna-Olivos J, Sánchez-García FJ. LprG and PE_PGRS33 Mycobacterium tuberculosis virulence factors induce differential mitochondrial dynamics in macrophages. Scand J Immunol. 2019, 1-10. doi: 10.1111/sji.12728.
- Echeverría-Valencia G, Silva-Miranda M, Ekaza E, Vallecillo A J, Parada C, Sada-Ovallec I, Altare F, Espitia C. Interaction of mycobacteria with Plasmin(ogen) affects phagocytosis and granuloma development. Tuberculosis. 2018, doi:org/10.1016/j.tube.2019.05.008.
- Guzmán-Gutiérrez SL, Silva-Miranda M, Krengel F, Huerta-Salazar E, León-Santiago M, Díaz-Cantón JK, Espitia C, Reyes-Chilpa R. Antimycobacterial Activity of Alkaloids and Extracts from Tabernaemontana alba and T. arborea. Planta Med. 2020, May 11. doi: 10.1055/a-1157-1732. [Epub ahead of print] PMID:32392600.
- Martínez, Roberto; Espitia-Pinzon, Clara I.; Silva Miranda, Mayra; Chávez-Santos, Rosa María; Pretelin-Castillo, Gustavo; Ramos-Orea, Aldahir; Hernández-Báez, Ángela M; Cotlame-Pérez, Sandra. Synthesis and antituberculosis activity of new acylthiosemicarbazides designed by structural modification. Drug Dev Res. 2020, May;81(3):350-355.doi: 10.1002/ddr.21626.
-Ortega PA, Silva-Miranda M, Torres-Larios A, Campos-Chávez E, Franken KCLCM, Ottenhoff THM, Ivanyi J, Espitia C*. Selection of a Single Domain Antibody, specific for an HLA-bound epitope of the Mycobacterial AG85B Antigen. Frontiers of Immunol. 2020, Oct 2;11:577815. doi: 10.3389/fimmu.2020.577815.
- Ortega-Tirado D, Niño-Padilla EI, Arvizu-Flores AA, Velázquez C, Espitia C, Serrano CJ, Enciso-Moreno JA, Sumoza-Toledo A, Garibay-Escobar A. Identification of immunogenic T-cell peptides of Mycobacterium Tuberculosis PE_PGRS33 protein. Mol Immunol. 2020, Sep;125:123-130. doi: 10.1016/J. Molimm.2020.06.026. Epub 2020 Jul 10.
- Garcia-Rodriguez, KM; Bini, EI; Gamboa-Dominguez, A; Espitia-Pinzon, CI; Huerta-Yepez, S; Bulfone-Paus, S; Hernandez-Pando, R, Differential mast cell numbers and characteristics in human tuberculosis pulmonary lesions, Scientific Reports. 2021,11(1). doi:org/10.1038/s41598-021-89659-6
- Gomez-Fuentes, S; Hernandez-de la Fuente, S; Morales-Ruiz, V; Lopez-Recinos, D; Guevara-Salinas, A; Parada-Colin, MC;Espitia, C; Ochoa-Leyva, A; Sanchez, F; Villalobos, N; Arce-Sillas, A; Hernandez, M; Mora, SI; Fragoso, G; Sciutto, E; Adalid-Peralta, L, A novel, sequencing-free strategy for the functional characterization of Taenia solium proteomic fingerprint, Plos Neglected Tropical Diseases. 2021, 15(2), 10.1371/journal.pntd.0009104,
- Valdez-Cruz, NA; Garcia-Hernandez, E; Espitia, C; Cobos-Marin, L; Altamirano, C; Bando-Campos, CG; Cofas-Vargas, LF;Coronado-Aceves, EW; Gonzalez-Hernandez, RA; Hernandez-Peralta, P; Juarez-Lopez, D; Ortega-Portilla, PA; Restrepo-Pineda, S; Zelada-Cordero, P; Trujillo-Roldan, MA, Integrative overview of antibodies against SARS-CoV-2 and their possibleapplications in COVID-19 prophylaxis and treatment, Microbial Cell Factories. 2021, 20(1), 10.1186/s12934-021-01576-5.
- Ramos-Orea, A; Ramirez-Apan, T; Chavez-Santos, RM; Aguayo-Ortiz, R; Espitia, C; Miranda, MS; Torres-Ochoa, RO;Martinez, R, Total syntheses and antiproliferative activities of prenostodione and its analogues, Organic & Biomolecular Chemistry. 2021, 19(38). doi.org/10.1039/d1ob00897h.
- Parada, C; Neri-Badillo, IC; Vallecillo, AJ; Segura, E; Silva-Miranda, M; Guzman-Gutierrez, SL; Ortega, PA; Coronado-Aceves, EW; Cancino-Villeda, L; Torres-Larios, A; Sanchez, MDA; Valdez, MAF; Espitia, C. New Insights into the Methylationof Mycobacterium tuberculosis Heparin Binding Hemagglutinin Adhesin Expressed in Rhodococcus erythropolis. Pathogens. 2021, 10(9), doi:10.3390/pathogens10091139.
-Castañeda-Fernandez C, Chávez-Santos RM, Silva-Miranda M, Espitia-Pinzón C, Martínez R, Kozina A.Optimization of rifampicin encapsulation in PLGA polymeric reservoirs.Int J Pharm. 2022 Jun 25;622:121844. doi: 10.1016/j.ijpharm.2022.121844. Epub 2022 May 21.PMID: 35605890
-Guzmán-Gutiérrez SL, Silva-Miranda M, Krengel F, Huerta-Salazar E, León-Santiago M, Díaz-Cantón JK, Espitia Pinzón C, Reyes-Chilpa R. Antimycobacterial Activity of Alkaloids and Extracts from Tabernaemontana alba and T. arborea. Planta Med. 2022 Jan;88(1):53-61. doi: 10.1055/a-1157-1732. Epub 2020 May 11.PMID: 32392600
- Carrero JC, Curay-Herrera V, Chacón-Niño L, Krengel F, Guzmán-Gutiérrez SL, Silva-Miranda M, González-Ramírez LC, Bobes RJ, Espitia C, Reyes-Chilpa R, Laclette JP. Potent Anti-amoebic Effects of Ibogaine, Voacangine and the Root Bark Alkaloid Fraction of Tabernaemontana arborea. Planta Med. 2022 Jul 22. doi: 10.1055/a-1809-1157


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