Contacto
Campos de conocimiento
Bioquímica
Fisiología Molecular
Neurobiología
Líneas de investigación
1. Estudio del potencial neuronal y dopaminérgico de células troncales embrionarias y células pluripotentes inducidas humanas in vitro e in vivo en el contexto de la Enfermedad de Parkinson.
2. Determinación del potencial neuronal y dopaminérgico de células troncales embrionarias de ratón y humanas a través de trasplantes en el sistema nervioso central.
3. Estudio de la neurogénesis del cerebro adulto en modelos murinos de daño neuronal (Parkinson y evento cerebrovascular isquémico).
Publicaciones
1. Ramos-Acevedo R, Morato-Torres CA, Francisco J. Padilla-Godínez, Bernal-Conde LD, Palomero-Rivero M, Faria Zafar, Luis Oskar Soto-Rojas, Schüle B, Guerra-Crespo M. 2023. Embryoid body cells from human embryonic stem cells overexpressing dopaminergic transcription factors survive and initiate neurogenesis via neural rosettes in the substantia nigra. Brain Sciences. 13(2):329. Como autor responsable. FI 3.333.
2. Pérez Segura Isaac, Santiago-Balmaseda Alberto, Rodríguez-Hernández Luis Daniel, Morales-Martínez Adriana, Martínez-Becerril Hilda Angélica, Martínez-Gómez Paola A., Delgado-Minjares Karen M., Salinas-Lara Citlaltepetl, Martínez-Dávila Irma A., Guerra-Crespo Magdalena, Pérez-Severiano Francisca, Soto-Rojas Luis O. 2023. PPARs and their neuroprotective effects in Parkinson´s disease: a novel therapeutic approach in α-synucleinopathy? International Journal of Molecular Sciences. 24(4):3264. FI 6.208.
3. Boronat-García A, Palomero-Rivero M, Guerra-Crespo M. 2023. Adrenal grafts in the central nervous system: Chromaffin and chromaffin progenitor cell transplantation. Methods in Molecular Biology Vol. 2565 Chromaffin Cells [SpringerNature]. Como autor responsable. FI 1.37.
4. Padilla-Godínez Francisco J, Ruiz-Ortega Leonardo I, Guerra-Crespo Magdalena. Nanomedicine in the Face of Parkinsons Disease: From Drug Delivery Systems to Nanozymes. 2022. Cells. 11(21):3445. Como autor responsable. FI 7.666.
5. Guerra-Crespo M, Collazo-Navarrete O, Ramos-Acevedo R, Morato-Torres CA, Schüle B. 2022. Embryoid body formation from mouse and human pluripotent stem cells for transplantation to study brain microenvironment and cellular differentiation. Methods Mol Biol. Como autor responsable. FI. 1.37.
6. Francisco J. Padilla-Godínez, Ramos-Acevedo R, Hilda Angélica Martínez-Becerril, Bernal-Conde LD, Garrido-Figueroa JF, Marcia Hiriart-Urdanivia, Adriana Hernández-López, Argüero-Sánchez R, Francesco Callea, Guerra-Crespo M. 2021. Protein Misfolding and Aggregation: The Connection between Parkinson’s Disease and Hepatic Endoplasmic Reticulum Storage Disorders. International Journal of Molecular Sciences. 22(22):12467. Como autor responsable. FI 6.208.
7. Collazo-Navarrete O, Hernández-García D, Guerrero-Flores G, Drucker-Colín R, Guerra-Crespo M, Covarrubias L. 2019. The substantia nigra is permissive and gains inductive signals when lesioned for dopaminergic differentiation of embryonic stem cells. Stem Cells and Development. 28(16):1104-1115. Como autor responsable.
FI 4.390.
8. Arzate-Vázquez DM, Guerra-Crespo M and Covarrubias L. 2019. Induction of typical and atypical neurogenesis in the adult substantia nigra after mouse embryonic stem cells transplantation. Neuroscience. 408: 308-326.
FI 3.708.
9. Guerrero-Flores G, Bastidas-Ponce A, Collazo-Navarrete O, Guerra-Crespo M and Covarrubias L. 2017. Functional determination of the differentiation potential of ventral mesencephalic neural precursor cells during dopaminergic neurogenesis. Developmental Biology. 429(1):56-70. FI 3.148.
10. Boronat-García A, Guerra-Crespo M, Drucker-Colín R. 2017. A Historical Perspective of Cell Transplantation in Parkinson’s disease. World Journal of Transplantation. 7(3):179-192.
