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Tutores

GERARDO ALFONSO CORZO BURGUETE

Instituto de Biotecnología (IBT)

Contacto

Teléfono: 777 3291602
Email: corzo@ibt.unam.mx
Sitio web: Visitar sitio web

Campos de conocimiento

Bioquímica
Biotecnología
Reconocimiento Molecular y Bioestructura

Líneas de investigación

Toxinas e interacción farmacológica
Expresión de proteínas en sistemas heterólogos

Publicaciones

Franco-Vasquez,A.M., Lazcano-Perez,F., Mejia-Sanchez,M.A., Corzo,G., Zamudio,F., Carbajal-Saucedo,A., Roman-Gonzalez,S.A., Gomez-Manzo,S., Arreguin-Espinosa,R. (2024). Structural, biochemical and immunochemical characterization of an acidic phospholipase A2 from Lachesis acrochorda (Viperidae: Crotalinae) venom. Toxicon, 237, 107528.
Articulo
Mendoza-Tobar,L.L., Clement,H., Arenas,I., Guerrero-Vargas,J.A., Hernandez-Orihuela,L., Cardoso-Arenas,S., Sepulveda-Arias,J.C., Corzo,G. (2024). Antimicrobial, toxicological, and antigenic characteristics of three scorpion venoms from Colombia: Centruroides margaritatus, Tityus pachyurus and Tityus n. sp. aff. metuendus. Acta Tropica, 252, 107134.
Open Access Artículo
Alvarado-Gonzalez,C., Clement,H., Ballinas-Casarrubias,L., Escarcega-Avila,A., Arenas-Sosa,I., Lopez-Contreras,K.S., Zamudio,F., Corzo,G., Espino-Solis,G.P. (2023). Identification and Venom Characterization of Two Scorpions from the State of Chihuahua Mexico: Chihuahuanus coahuliae and Chihuahuanus crassimannus. Toxins (Basel), 15 (7), 416.
Open Access Artículo
Clement,H., Corrales-Garcia,L.L., Rivas-Mercado,E., Garza-Ocanas L., Corzo,G. (2023). cDNA Cloning, Heterologous Expression, Cytotoxicity, and Inhibitory Effects of a Disintegrin from Bothrops ammodytoides Venom. International Journal of Peptide Research and Therapeutics, 29 (4), 54.
Artículo
Ibarra-Vega,R., Jimenez-Vargas,J.M., Pineda-Contreras,A., Martinez-Martinez,F.J., Barajas-Saucedo,C.E., Garcia-Ortega,H., Magana-Vergara,N.E., Possani,L.D., Corzo,G., Gaitan-Hinojosa,M.A., Vazquez-Vuelvas,O.F., Zamudio,F., Valdez-Velazquez,L.L. (2023). Indolealkylamines in the venom of the scorpion Thorellius intrepidus. Toxicon, 233, 107232.
Revisión
Juarez-Lopez,D., Morales-Ruiz,E., Herrera-Zuniga,L.D., Gonzalez-Carrera,Z., Cuevas-Reyes,E., Corzo,G., Schcolnik-Cabrera,A., Villegas,E. (2023). The resilience of Pseudomonas aeruginosa to antibiotics, and the designing of antimicrobial peptides to overcome microbial resistance. Current Medicinal Chemistry, 30 (1), 72-103.
Open Access Artículo in press
Mendoza-Tobar,L.L., Clement,H., Arenas,I., Guerrero-Vargas,J.A., Sepulveda-Arias,J.C., Corzo,G. (2023). An overview of some enzymes from buthid scorpion venoms from Colombia: Centruroides margaritatus, Tityus pachyurus and Tityus n. sp. aff. Metuendus. Journal of Venomous Animals and Toxins including Tropical Diseases., aceptado.
Artículo
Montero-Dominguez,P.A., Corzo,G. (2023). Characterization of the coupling mechanism of scorpion B -neurotoxins on the voltage-gated sodium channel hNav1.6. Journal of Biomolecular Structure and Dynamics, 41 (23), 14419-14427 .
Artículo
Salazar,M.H., Ortiz,M.H., Encarnacion,S., Zamudio,F., Possani,L.D., Cleghorn,J., Moran,M., Acosta,H., Corzo,G. (2023). A proteomic overview of the major venom components from Tityus championi from Panama. Toxicon, 227, 107082.
Open Access Artículo
Vasquez-Escobar,J., Benjumea-Gutierrez,D.M., Lopera,C., Clement,H.C., Bolanos,D.I., Higuita-Castro,J.L., Corzo,G.A., Corrales-Garcia,L.L. (2023). Heterologous Expression of an Insecticidal Peptide Obtained from the Transcriptome of the Colombian Spider Phoneutria depilate. Toxins (Basel), 15 (7), 436.
Open Access Artículo
Cardoso-Arenas,S., Clement,H., Arenas,I., Olvera,F., Caliskan,F., Corrales-Garcia,L.L., Corzo,G. (2022). Recombinant expression and antigenicity of two peptide families of neurotoxins from Androctonus sp. Journal of Venomous Animals and Toxins Including Tropical Diseases, 28, e20220026.
Open Access Artículo
Mejia-Sanchez,M.A., Clement, H., Corrales-Garcia,L.L., Olamendi-Portugal,T., Carbajal,A., Corzo,G. (2022). Crotoxin B: Heterologous Expression, Protein Folding, Immunogenic Properties, and Irregular Presence in Crotalid Venoms. Toxins, 14 (6), 382.
Open Access Artículo
Rodriguez-Vargas,A., Vega,N., Reyes-Montano,E., Corzo,G., Neri-Castro,E., Clement,H., Ruiz-Gomez,F. (2022). Intraspecific Differences in the Venom of Crotalus durissus cumanensis from Colombia. Toxins, 14 (8), 532.
Open Access Artículo
Salazar,M.H., Clement,H., Corrales-Garcia,L.L., Sanchez,J., Cleghorn,J., Zamudio,F., Possani,L.D., Acosta,H., Corzo,G. (2022). Heterologous expression of four recombinant toxins from Panamanian scorpions of the genus Tityus and Centruroides for production of antivenom. Toxicon: X, 13, 100090.
Open Access Artículo
Santana,F.L., Estrada,K., Alford,M.A., Wu,B.C., Dostert,M., Pedraz,L., Akhoundsadegh,N., Kalsi,P., Haney,E.F., Straus,S.K., Corzo,G., Hancock,R.E.W. (2022). Novel Alligator Cathelicidin As-CATH8 Demonstrates Anti-Infective Activity against Clinically Relevant and Crocodylian Bacterial Pathogens. Antibiotics (Basel), 11 (11), 1603.
Open Access Artículo
Tuxpan-Perez,A., Ibarra-Valencia,M.A., Estrada,B.E., Clement,H., Corrales-Garcia,L.L., Espino-Solis,G.P., Corzo,G. (2022). Antimicrobial and Immunomodulatory Effects of Selected Chemokine and Antimicrobial Peptide on Cytokine Profile during Salmonella Typhimurium Infection in Mouse. Antibiotics, 11 (5), 607.
Open Access Artículo
Vasquez-Escobar,J., Romero-Gutierrez,T., Morales,J.A., Clement,H.C., Corzo,G.A., Benjumea,D.M., Corrales-Garcia,L.L. (2022). Transcriptomic Analysis of the Venom Gland and Enzymatic Characterization of the Venom of Phoneutria depilata (Ctenidae) from Colombia. Toxins, 14 (5).
Open Access Artículo
Alvarado,D., Cardoso-Arenas,S., Corrales-Garcia,L.L., Clement,H., Arenas,I., Montero-Dominguez,P.A., Olamendi-Portugal,T., Zamudio,F., Agota,C., Borrego,J., Panyi,G., Papp,F., Corzo,G. (2021). A Novel Insecticidal Spider Peptide that Affects the Mammalian Voltage-Gated Ion Channel hKv1.5. Frontiers in Pharmacology, 11, 563858.
Artículo
Archundia,I.G., de la Rosa,G., Olvera,F., Calderon,A., Benard-Valle,M., Alagon,A., Corzo,G. (2021). Assessment of neutralization of Micrurus venoms with a blend of anti-Micrurus tener and anti-ScNtx antibodies. Vaccine, 39 (6), 1000-1006.
Open Access Artículo
Ibarra-Valencia,M.A., Espino-Solis,G.P., Estrada,B.E., Corzo,G. (2021). Immunomodulatory Responses of Two Synthetic Peptides against Salmonella Typhimurium Infection. Molecules, 26 (18), 5573.
Artículo
Jimenez-Vargas,J.M., Ramirez-Carreto,S., Corzo,G., Possani,L.D., Becerril,B., Ortiz,E. (2021). Structural and functional characterization of NDBP-4 family antimicrobial peptides from the scorpion Mesomexovis variegatus. Peptides, 141, 170553.
Revision
Santana,F.L., Estrada,K., Ortiz,E., Corzo,G. (2021). Reptilian beta-defensins: expanding the repertoire of known crocodylian peptides. Peptides, 136, 170473.
Open Access Artículo
Santana,F.L., Arenas,I., Haney,E.F., Estrada,K., Hancock,R.E.W., Corzo,G. (2021). Identification of a crocodylian ×ý-defensin variant from Alligator mississippiensis with antimicrobial and antibiofilm activity. Peptides, 141, 170549.
Artículo
Arenas,I., Ibarra,M.A., Santana,F.L., Villegas,E., Hancock,R.E.W., Corzo,G. (2020). In vitro and in vivo antibiotic capacity of two host defence peptides. Antimicrobial Agents and Chemotherapy, 64 (7), e00145-20.
Artículo
Bertrand,B., Munusamy,S., Espinosa-Romero,J.F., Corzo,G., Arenas-Sosa,I., Galvan-Hernandez,A., Ortega-Blake,I., Hernandez-Adame,P.L., Ruiz-Garcia,J., Velasco-Bolom,J.L., Garduno-Juarez,R., Munoz-Garay,C. (2020). Biophysical characterization of the insertion of two potent antimicrobial peptides-Pin2 and its variant Pin2[GVG] in biological model membranes. Biochimica et Biophysica Acta (BBA) - Biomembranes, 1862 (2), 183105.
Artículo
Borrego,J., Clement,H., Corrales-Garcia,L.L., Arenas,I., Corzo,G. (2020). Key amino acid residues involved in mammalian and insecticidal activities of Magi4 and Hv1b, cysteine-rich spider peptides from the delta-atracotoxin family. Amino Acids, 52, 465?475.
Artículo
Corrales-Garcia,L.L., Serrano-Carreon,L., Corzo,G. (2020). Improving the heterologous expression of human beta-defensin 2 (HBD2) using an experimental design. Protein Expression and Purification, 167, 105539.
Artículo
Lino-Lopez,G.J., Valdez-Velazquez,L.L., Corzo,G., Romero-Gutierrez,T., Jimenez-Vargas,J.M., Rodriguez-Vazquez,A., Vazquez-Vuelvas,O.F., Gonzalez-Carrillo,G. (2020). Venom gland transcriptome from Heloderma horridum horridum by high-throughput sequencing. Toxicon, 180, 62-78.
Open Access Artículo
Pelaez-Coyotl,E.A., Barrios-Palacios J., Mucino,G., Moreno-Blas,D., Costas,M., Montiel-Montes T., Diener,C., Uribe-Carvajal,S., Massieu,L., Castro-Obregon,S., Espinosa,O.R., Barrios-Payan,J., Leon-Contreras,J.C., Corzo,G., Hernandez-Pando,R., Del Rio,G. (2020). Antimicrobial Peptide against Mycobacterium Tuberculosis That Activates Autophagy Is an Effective Treatment for Tuberculosis. Pharmaceutics, 12 (11), 1071.
Artículo
Rodriguez, A., Pedersen, M. O., Villegas, E., Rivas-Santiago, B., Villegas-Moreno, J., Amero, C., Norton, R. S., Corzo, G. (2020). Antimicrobial activity and structure of a consensus human beta-defensin and its comparison to a novel putative hBD10. Proteins: Structure, Function and Bioinformatics, 88 (1), 175-186.
Artículo
Velasco-Bolom,J.L., Corzo,G., Garduno-Juarez,R. (2020). Folding profiles of antimicrobial scorpion venom-derived peptides on hydrophobic surfaces: a molecular dynamics study. Journal of Biomolecular Structure and Dynamics, 38 (10), 2928-2938.
Artículo
Bondarenko,O., Corzo,G., Santana,F.L., del Rio-Portilla,F., Darszon,A., Lopez-Gonzalez,I. (2019). Non-enzymatically oxidized arachidonic acid regulates T-type Ca(2+) currents in mouse spermatogenic cells. FEBS Letters, 593 (14), 1735-1750.
Artículo
Clement, H., Corzo, G., Neri-Castro, E., Arenas, I., Hajos, S., de Roodt, A. R., Villegas, E. (2019). cDNA cloning, heterologous expression, protein folding and immunogenic properties of a phospholipase A2 from Bothrops ammodytoides venom. Protein Expression and Purification, 154, 33-43.
Open Access Artículo
Clement,H., Corrales-Garcia,L.L, Bolanos,D., Corzo,G., Villegas,E. (2019). Immunogenic Properties of Recombinant Enzymes from Bothrops Ammodytoides Towards the Generation of Neutralizing Antibodies against Its Own Venom. Toxins (Basel), 11 (12), 702.
Open Access Artículo
de la Rosa,G., Olvera,F., Archundia,I.G., Lomonte,B., Alagon,A., Corzo,G. (2019). Horse immunization with short-chain consensus a-neurotoxin generates antibodies against broad spectrum of elapid venomous species. Nature Communications, 10 (1), 3642.
Open Access Artículo
Navarro-Gonzalez, S. S., Ramirez-Trujillo, J. A., Pena-Chora, G., Gaytan, P., Roldan-Salgado, A., Corzo, G., Lina-Garcia, L. P., Hernandez-Velazquez, V. M., Suarez-Rodriguez, R. (2019). Enhanced Tolerance against a Fungal Pathogen and Insect Resistance in Transgenic Tobacco Plants Overexpressing an Endochitinase Gene from Serratia marcescens. International Journal of Molecular Sciences, 20 (14), 3482.
Open Access Artículo
Okada,M., Ortiz,E., Corzo,G., Possani,L.D. (2019). Pore-forming spider venom peptides show cytotoxicity to hyperpolarized cancer cells expressing K+ channels: A lentiviral vector approach. PLoS ONE, 14 (4), e0215391.
Artículo
de la Rosa G., Olvera,F., Cruz,E., Paniagua,D., Corzo,G. (2018). Use of irradiated elapid and viperid venoms for antivenom production in small and large animals. Toxicon, 155, 32-37.
Artículo
de la Rosa G., Corrales-Garcia, L.L., Rodriguez-Ruiz, X., Lopez-Vera, E., Corzo, G. (2018). Short-chain consensus alpha-neurotoxin: a synthetic 60-mer peptide with generic traits and enhanced immunogenic properties. Amino Acids, 50 (7), 885-895.
Artículo
Guerrero-Garzon, J.F., Benard-Valle, M., Restano-Cassulini, R., Zamudio, F., Corzo, G., Alagon, A., Olvera-Rodriguez, A. (2018). Cloning and sequencing of three-finger toxins from the venom glands of four Micrurus species from Mexico and heterologous expression of an alpha-neurotoxin from Micrurus diastema. Biochimie, 147, 114-121.
Circuito de Posgrado, Ciudad Universitaria
Alcaldía Coyoacán, C.P. 04510, México, CDMX

55 5623 7006
mdcbq@posgrado.unam.mx
UNAM Posgrado