El Laboratorio de Biología Computacional (CompBioLab) se creó en 2006, con el objetivo de llevar a cabo investigación teórica básica, principalmente en el área del modelado de redes de regulación. Gracias a la gran cantidad de información molecular disponible, es posible reconstruir redes de regulación que controlan diversos procesos biológicos.

Publicaciones

David Martínez-Méndez, Luis Mendoza, Carlos Villareal, and Leonor Huerta (2021)
Continuous modeling of T CD4 lymphocyte activation and function.
Frontiers in Immunology 12: 743559 https://doi.org/10.3389/fimmu.2021.743559
FI: 7.561

Juan Voutssas-Lara, Jacquelynne Cervantes-Torres, Marisela Hernández, Raúl J. Bobes, Edmundo Lamoyi, Ricardo A. Vázquez-Ramírez, Luis Mendoza, Karen L. Reyes-Barrera, Rogelio López-Martínez, Ángel G. Alpuche-Solís, Sergio Rosales-Mendoza, Leonor Huerta, Gladis Fragoso, and Edda Sciutto (2021).
Influence of adjuvants on the amount, specificity and functional activity of antibody response to human influenza vaccine in mice.
Molecular Immunology 135: 398-407 https://doi.org/10.1016/j.molimm.2021.05.003
FI: 3.641

Wencheng Yin, Luis Mendoza, Jimena Monzon-Sandoval, Araxi O. Urrutia, and Humberto Gutierrez (2021).
Emergence of co-expression in gene regulatory networks.
PLoSONE 16(4):e0247671 https://doi.org/10.1371/journal.pone.0247671
FI: 3.240

Jennifer Enciso, Luis Mendoza, Elena R. Álvarez-Buylla, and Rosana Pelayo (2020).
Dynamical modeling predicts an inflammation-inducible CXCR7+ B cell precursor with potential implications in lymphoid blockage pathologies.
PeerJ 8: e9902
FI: 2.984

David Martínez-Méndez, Carlos Villareal, Luis Mendoza, and Leonor Huerta (2020).
An integrative network modeling approach to T CD4 cell activation.
Frontiers in Physiology 11: 380.
FI: 4.134

Nathan Weinstein, Luis Mendoza, and Elena R. Álvarez-Buylla (2020).
A computational model of the endothelial to mesenchymal transition.
Frontiers in Genetics 11: 40.
FI: 3.789

Alfredo Rodríguez, J. Jesús Naveja, Leda Torres, Benilde García de Teresa, Ulises Juárez-Figueroa, Cecilia Ayala, Eugenio Martín Azpeitia, Luis Mendoza, and Sara Frías (2019).
WIP1 contributes to the adaptation of Fanconi anemia cells to DNA damage as determined by the regulatory network of the Fanconi anemia and checkpoint recovery pathways.
Frontiers in Genetics 10: 411.
FI: 3.789

Israel Canela-Pérez, Imelda López-Villaseñor, Luis Mendoza, Ana María Cevallos, and Roberto Hernández (2019).
Nuclear localization signals in trypanosomal proteins.
Molecular and Biochemical Parasitology 229: 15-23.
FI: 1.759

Cynthia Raquel Trejo-Muñoz, Ricardo Vázquez-Ramírez, Luis Mendoza, and Carlos Kubli-Garfias (2018).
Biophysical Mechanism of the SAHA Inhibition of Zn2+-Histone Deacetylase-Like Protein (FB188 HDAH) Assessed via Crystal Structure Analysis.
Computational Molecular Bioscience 8: 91-114.
FI: 0.55

Adhemar J. Liquitaya-Montiel and Luis Mendoza (2018).
Dynamical analysis of the regulatory network controlling Natural Killer cells differentiation.
Frontiers in Physiology 9: 1029.
FI: 4.134

Carlos Ramírez and Luis Mendoza (2018).
Phenotypic stability and plasticity in GMP-derived cells as determined by their underlying regulatory network.
Bioinformatics 34: 1174-1182.
FI: 6.937

Nathan Weinstein, Luis Mendoza, Isidoro Gitler, and Jaime Klapp (2017).
A network model to explore the effect of the micro-environment on endothelial cell behavior during angiogenesis.
Frontiers in Physiology 8: 960.
FI: 4.134

Eugenio Azpeitia, Stalin Munoz, Daniel Gonzalez-Tokman, Mariana Esther Martinez-Sanchez, Nathan Weinstein, Aurelien Naldi, Elena ER Alvarez-Buylla, David A Rosenblueth, and Luis Mendoza (2017).
The combination of the functionalities of feedback circuits is determinant for the number and size of attractors of molecular networks.
Scientific Reports 7: 42023
FI: 5.133

Jennifer Enciso, Hector Mayani, Luis Mendoza, and Rosana Pelayo (2016).
Modeling the pro-inflammatory tumor microenvironment in acute lymphoblastic leukemia predicts a breakdown of hematopoietic-mesenchymal communication networks.
Frontiers in Physiology 7: 349.
FI: 4.134

Akram Méndez and Luis Mendoza (2016).
A Network Model to Describe the Terminal Differentiation of B Cells.
PLOS Computational Biology 12: e1004696.
FI: 4.475

Circuito de Posgrado, Ciudad Universitaria
Alcaldía Coyoacán, C.P. 04510, México, CDMX

55 5623 7006
mdcbq@posgrado.unam.mx