1.Biología molecular y celular de la infección por virus gastrointestinales
• Caracterización del ciclo de replicación
• Apropiación de la maquinaria de síntesis de proteínas
• Control de la respuesta inmune innata de la célula

2. Diagnóstico, epidemiología y metagenómica viral
• Epidemiología de virus respiratorios y gastrointestinales
• Viroma de los tractos respiratorio e intestinal

3. Epidemiología evolución de virus emergentes y reemergentes
• SARS-CoV-2
• Influenza

Publicaciones

147. Zárate S, Taboada B, Yocupicio-Monroy, M, Arias CF. The Human Virome. Arch Med Res. 2017 Nov;48(8):701-716. doi: 10.1016/j.arcmed.2018.01.005. Citas = 2

148. Casorla-Pérez L, López T, López S, and Arias CF. The ubiquitin-proteasome system is necessary for the efficient replication of human astrovirus. J Virol. 2018 doi: 10.1128/JVI.01809-17. Citas = 2

149. Trejo-Cerro O, Eichwald C, Schraner EM, Silva-Ayala D, López S, Arias CF. Actin-dependent non-lytic rotavirus exit and infectious virus morphogenetic pathway in non-polarized cells. J Virol 92:e02076-17. 2018. doi: 10.1128/JVI.02076-17. Citas = 2

150. Díaz-Salinas MA, Casorla LA, López T, López S and Arias CF. Most rotavirus strains require the cation-independent mannose-6-phosphate receptor, sortilin-1, and cathepsins to enter cells. Virus Res. 2018 Feb 2;245:44-51. doi: 10.1016/j.virusres.2017.12.002. Citas = 0

151. Elizondo-Quiroga D, Medina-Sánchez A, Sánchez-González JM, Eckert KA, Villalobos-Sánchez E, Navarro-Zúñiga AR, Sánchez-Tejeda G, Correa-Morales F, González-Acosta C, Arias CF, López S, del Ángel RM, Pando-Robles V, and Elizondo-Quiroga AE. Zika Virus in Salivary Glands of Five Different Species of Wild-Caught Mosquitoes from Mexico. Sci Rep. 2018 Jan 16;8(1):809. doi: 10.1038/s41598-017-18682-3. Citas = 14

152. Taboada B, Isa P, Gutiérrez AL, del Ángel RM, Ludert JE, Vázquez-Salvador N; Tapia-Palacios MA, Chávez P, Garrido E, Espinosa AC, Eguiarte LE, López S, Souza V, Arias CF. The viral structure of the Cuatro Ciénegas Basin, a unique oasis in Northern Mexico, reveals a highly diverse population at a small geographic scale. Appl Environ Microbiol. 2018 Apr 6. pii: AEM.00465-18. doi: 10.1128/AEM.00465-18. Citas = 3

153. Zepeda Mendoza ML, Xiong Z, Escalera-Zamudio M, Runge Ak, Thézé J, Streicker D, Frank HK, Loza-Rubio E, Liu S, Ryder OA, Samaniego Castruita JA, Katzourakis A, Taboada B, Löber U, Pybus OG, Li Y, Rojas-Anaya E, Bohmann K, Carmona Baez A, Arias CF, Liu S, Greenwood AD, Bertelsen MF, White NE, Bunce M, Zhang G, Sicheritz-Pontén T, Thomas M, and Gilbert P. Hologenomic adaptations underlying the evolution of sanguivory in the common vampire bat. Nature Evol Ecol. 2018 Apr;2(4):659-668. doi: 10.1038/s41559-018-0476-8. Citas = 12

154. Parrón JA, Ripollés A, Sánchez AC, Pérez MD, Calvo M, López S, Arias CF, and Sánchez L. Antirotaviral activity of bovine milk fractions: seeking a better understanding of neutralization mechanism. J Funct Foods. 2018, 44:103-111. doi.org/10.1016/j.jff.2018.03.002 Citas = 2

155. Thézé J, Li T, Plessis LD, Bouquet J, Kraemer MUG, Somasekar S, Yu G, Angel MC,
Kuan G, Harris E, Wu C, Ansari MA, Bowden R, Faria NR, Yagi S, Messenger S, Brooks T, Stone M, Bloch EM, Busch M, Muñoz-Medina JE, González-Bonilla CR, Wolinsky S, López S, Arias CF, Bonsall D, Chiu CY, Pybus OG. 2018. Genomic epidemiology reconstructs the introduction and spread of Zika virus in Central America and Mexico. Cell Host and Microbe, May 15. pii: S1931-3128(18)30218-X. doi: 10.1016/j.chom.2018.04.017. Citas = 6

156. Aguilar-Hernández N, López S, Arias CF. Minimal capsid composition of infectious human astrovirus. 2018. Virology. 521:58-61. 10.1016/j.virol.2018.05.021. Citas = 1

157. Oceguera A, Peralta AV, Martínez-Delgado G, Arias CF, López S. Rotavirus RNAs sponge host cell RNA binding proteins and interfere with their subcellular localization. Virology. 2018. 525:96-105. doi: 10.1016/j.virol.2018.09.013. Citas = 2

158. Espinosa R, López T, Bogdanoff WA, Espinoza MA, López S, DuBois RM, Arias CF. Isolation of neutralizing monoclonal antibodies to human astrovirus and characterization of virus variants that escape neutralization. J Virol. 2018 Oct 24. pii: JVI.01465-18. doi: 10.1128/JVI.01465-18. Citas = 0

159. Trejo-Cerro O, Aguilar-Hernández N, Silva-Ayala D, López S, Arias CF. The actin cytoskeleton is important for rotavirus internalization and RNA genome replication. Virus Res. 263:27-33, 2019. Citas = 0

160. Meyer L, López T, Espinosa R, Arias CF, Vollmers C, DuBois RM. A Simplified Workflow for Monoclonal Antibody Sequencing. PLOS One 2019. Jun 24;14(6):e0218717. doi: 10.1371/journal.pone.0218717.

161. Garcés Y, Martínez JL, Hernández DT, Hernández HO, Méndez M, Wood CD, Rendón Mancha JM, Silva-Ayala D, López S, Guerrero A, Arias CF. Nanoscale organization of rotavirus replication machineries. eLife. 2019 Jul 25;8. pii: e42906. doi: 10.7554/eLife.42906

162. Martínez JL, Arnoldi F, Schraner EM, Eichwald C, Silva-Ayala D, Lee E, Sztul E, Burrone OR, López S, and Arias CF. The guanine nucleotide exchange factor GBF1 participates in rotavirus replication. J. Virol. 2019 Jul 3. pii: JVI.01062-19. doi: 10.1128/JVI.01062-19

163. Sandoval-Jaime C, Guzmán-Ruiz L, López S, and Arias CF. Development of a novel DNA based reverse genetic system for classic human astroviruses. Virology. Jul 4;535:130-135. doi: 10.1016/j.virol.2019.07.005

164. Escalera-Zamudio M, Cobián-Güemes AG, Taboada B, López Martínez I, Vázquez-Pérez JA, Montalvo-Corral M, Hernandez J, Barrera Badillo G, López S, Arias CF, and Iša P. Efficient whole genome sequencing of influenza A viruses. BioRixv. 2019 doi.org/10.1101/749234.

165. Deng X, Achari A, Federman S, Yu G, Somasekar S, Mbala P, Kapetshi J, Ahuka S, Muyembe-Tamfum JJ, Ahmed A, Tamhankar M, Patterson JL, Ndembi N, Mbanya D, Kaptue L, McArthur C, Muñoz-Medina JE, Gonzalez-Bonilla CR, López S, Arias CF, Arevalo S, Miller S, Rodgers M, Cloherty G, Hackett J, and Chiu CY. 2020. Metagenomic sequencing with spiked primer enrichment (MSSPE) for viral diagnostics, surveillance, and discovery. Nature Microbiol. 5:443-454. DOI: 10.1038/s41564-019-0637-9

166. López S, Arias CF. 2020 Genómica de rotavirus. Impacto en salud pública. Salud Pub Mex. 62:36-41. https://doi.org/10.21149/9965

167. Martinez JL and Arias CF. 2020. Role of the guanine nucleotide exchange factor GBF1 in the replication of RNA viruses. Viruses, 12, 682. doi: 10.3390/v12060682

168. Isa P, Perez-Delgado A, Quevedo IR, Lopez S, Arias CF. 2020. Rotaviruses Associate with Distinct Types of Extracellular Vesicles. Viruses, 12, 763. doi: 10.3390/v12070763

169. Taboada B, Vazquez-Perez JA, Munoz-Medina JE, Ramos-Cervantes P, Escalera-Zamudio M, Boukadida C, Sanchez-Flores A, Isa P, Mendieta-Condado E, Martinez-Orozco JA, Becerril-Vargas E, Salas-Hernandez J, Grande R, Gonzalez-Torres C, Gaytan-Cervantes FJ, Vazquez G, Pulido F, Araiza-Rodriguez A, Garces-Ayala F, Gonzalez-Bonilla CR, Grajales-Muniz C, Borja-Aburto V, Barrera-Badillo G, Lopez S, Hernandez-Rivas L, Perez-Padilla R, Lopez-Martinez I, Avila-Rios S, Ruiz-Palacios G, Ramirez-Gonzalez JE, Arias CF. 2020. Genomic analysis of early SARS-CoV-2 variants introduced in Mexico. J. Virol, 94. doi: 10.1128/JVI.01056-20

170. Aguado-Garcia Y, Taboada B, Moran P, Rivera-Gutierrez X, Serrano-Vazquez A, Isa P, Rojas-Velazquez L, Perez-Juarez H, Lopez S, Torres J, Ximenez C, Arias CF. 2020. Tobamoviruses can be frequently present in the oropharynx and gut of infants during their first year of life. Sci. Rep. 10, 13595. doi: 10.1038/s41598-020-70684-w

171. Moreno-Contreras J, Espinoza MA, Sandoval-Jaime C, Cantú-Cuevas MA, Barón-Olivares H, Ortiz-Orozco OD, Muñoz-Rangel AV, Hernández-de la Cruz M, Eroza-Osorio CM, Arias CF, López S. 2020 Saliva sampling and Its direct Lysis, an excellent option to increase the number of SARS-CoV-2 diagnostic tests in settings with supply shortages. J Clin Microbiol. 58(10):e01659-20. doi: 10.1128/JCM.01659-20.

172. Aguilar-Hernández N, Meyer L, López S, DuBois RM, Arias CF. 2020. Protein disulfide isomerase A4 is involved in genome uncoating during human astrovirus cell entry. Viruses 13:53. doi: 10.3390/v13010053.

173. Grupo Técnico Asesor de Vacunación Covid-19. 2020. Priorización inicial y consecutiva para la vacunación contra SARS-CoV-2 en la población mexicana. Recomendaciones preliminares. Salud Pub Mex. doi.org/10.21149/12399.

174. Taboada B, Morán P, Serrano-Vázquez A, Iša P, Rojas-Velázquez L, Pérez-Juárez H, López S, Torres J, Ximenez C, Arias CF. 2021. The gut virome of healthy children during the first year of life is diverse and dynamic. PLOS ONE 16:e0240958. doi: 10.1371/journal.pone.0240958.

175. Arias CF, Lopez S. 2021. Rotavirus cell entry: not so simple after all. Curr Op Virol 49:42–48. doi: 10.1016/j.coviro.2021.03.011

176. Grupo Técnico Asesor de Vacunación Covid-19. 2021. Actualización del análisis de priorización de las vacunas para COVID-19 en México y recomendaciones generadas. Diseminación Rápida, Salud Pub Mex. doi.org/10.21149/12571

177. Rodríguez Maldonado AP, Cedro-Tanda A, Vázquez-Pérez JA, Taboada B, Boukadida C, Wong-Arámbula C, Nuñez-García TE, Cruz-Ortiz N, Barrera-Badillo G, Mendieta Condado E, Hernández-Rivas L, López-Martínez I, Mendoza-Vargas A, Reyes-Grajeda JP, Alcaraz N, Peñaloza-Figueroa F, Gonzalez-Barrera D, Rangel-DeLeon D, Ramirez-Vega O, Munguia-Garza P, Garcia-Cárdenas FJ, González-Woge MA, Cisneros-Villanueva M, Miranda-Ortiz H, Rosas-Escobar P, Mejía-Nepomuceno F, Hernández-Terán A, Mújica-Sánchez M, Becerril-Vargas E, Martínez-Orozco JA, Pérez-Padilla R, Salas-Hernández J, Sánchez-Flores A, Isa P, Matías-Florentino M, Ávila-Ríos S, Muñoz-Medina JE, Grajales-Muñiz C, Salas-Lais AG, Santos Coy-Arechavaleta A, Hidalgo-Miranda A, Arias CF, Ramírez-González, JE. 2021. Emergence and spread of the potential variant of interest (VOI) B.1.1.519 predominantly present in Mexico. Arch Virol 166:3173-3177. doi: 10.1007/s00705-021-05208-6.

178. Ricemeyer L, Aguilar-Hernández N, López T, Espinosa R, Lanning S, Mukherjee S, Cuellar C, López S, Arias CF, and DuBois RM. 2021. Structures of two human astrovirus capsid neutralizing Antibody complexes reveal distinct epitopes and inhibition of virus attachment to cells. J Virol. JVI0141521. doi: 10.1128/JVI.01415-21.

179. Báez-N C, Quevedo Partida IR, Arias CF, López S, Iša P. 2021. The association of human astrovirus with extracellular vesicles facilitates cell infection and protects the virus from Neutralizing antibodies.. J Virol. 2022 Jun 28:e0084822. doi: 10.1128/jvi.00848-22

180. Taboada B, Zárate S, Iša P, Boukadida C, Vazquez-Perez A, Muñoz-Medina JE, Ramírez-González JE, Comas García A, Grajales-Muñiz C, Rincón-Rubio A, Matías-Florentino M., Sanchez-Flores A, Mendieta-Condado M, Verleyen J, Barrera-Badillo G, Hernández-Rivas L, Mejía-Nepomuceno F, Martínez-Orozco JA, Becerril-Vargas E, López S, López-Martínez I, Ávila-Ríos S, Arias CF. 2021. Genetic Analysis of SARS-CoV-2 variants in Mexico during the first year of the COVID-19 pandemic. Viruses 2021, 13, 2161. doi.org/10.3390/v13112161

181. Janowski AB, Owen MC, Dudley H, López T, Espinosa M, Elvin-Lewis M, Colichone A, Arias CF, Burbelo PD, Wang D. 2021. High seropositivity rate of neutralizing antibodies to astrovirus VA1 in human populations. mSphere 6(5):e0048421. doi: 10.1128/mSphere.00484-21.

182. Rivera-Gutiérrez X, Morán P, Taboada B, Serrano-Vazquez A, Isa P, Rojas-Velázquez L, Pérez-Juárez H, López S, Torres J, Ximénez C, Arias CF. 2022. High prevalence and diversity of caliciviruses in a community setting determined by random, next generation sequencing. Microbiol Spectr 10(1):e0185321. doi: 10.1128/spectrum.01853-21

183. Boukadida C, Taboada B, Escalera-Zamudio M, Isa P , Ramírez-González JE, Vazquez-Perez JA, Muñoz- Medina JE, Grajales-Muñiz C, González-Torres C , Gaytán-Cervantes FJ, Rincón-Rubio A, Matías-Florentino M, Paz-Juárez HE, Sanchez-Flores A, Mendieta-Condado E, Barrera-Badillo G, Hernández-Rivas L, López S, López-Martínez I, Ávila-Ríos S, Arias CF. 2022. Genomic characterization of SARS-CoV-2 isolated from patients with distinct disease outcomes in Mexico. Microbiol Spectr 10(1):e0124921. doi: 10.1128/spectrum.01249-21.

184. Moreno-Contreras J, Espinoza MA, Sandoval-Jaime C, Cantú-Cuevas MA, Madrid D, Barón-Olivares H, Ortiz-Orozco OD, Muñoz-Rangel AV, Hernández-de la Cruz M, Eroza-Osorio CM, Arias CF, López S. 2022. Pooling saliva samples as an excellent option to increase the surveillance for SARS-CoV-2 when re-opening community settings. PLOS ONE. 17(1):e0263114. doi: 10.1371/journal.pone.0263114.

185. Martínez JL, Eichwald C, Schraner EM, López S, Arias CF. 2022. Lipid metabolism is involved in the association of rotavirus viroplasms with endoplasmic reticulum membranes.
Virology. 569:29-36. doi: 10.1016/j.virol.2022.02.005.

186. Zárate S, Taboada B, Muñoz-Medina JE, Iša P, Sanchez-Flores A, Boukadida C, Herrera-Estrella A, Selem Mojica N, Rosales-Rivera M, Gómez-Gil B, Salas-Lais AG, Santacruz-Tinoco CE, Montoya-Fuentes H, Alvarado-Yaah JE, Molina-Salinas GM, Espinoza-Ayala GE, Enciso-Moreno JA, Gutiérrez-Ríos RM, Loza A, Moreno-Contreras J, García-López R, Rivera-Gutierrez X, Comas-García A, Wong-Chew RM, Jiménez MA, del Angel RM, Vazquez-Perez JA, Matías-Florentino M, Pérez-García M, Ávila-Ríos S, Castelán-Sánchez HG, Delaye L, Martínez-Castilla LP, Escalera-Zamudio M, López S, Arias CF. 2022. The Alpha variant (B.1.1.7) of SARS-CoV-2 failed to become dominant in Mexico. 2022. Microbiol Spectr. 10(2):e0224021. doi: 10.1128/spectrum.02240-21.

187. Taboada B, Zárate S, García-López R, Muñoz-Medina JE, Sanchez-Flores A, Herrera-Estrella A, Boukadida C, Gómez-Gil B, Selem Mojica N, Rosales-Rivera M, Salas-Lais AG, Gutiérrez-Ríos RM, Loza A, Rivera-Gutierrez X, Vazquez-Perez JA, Matías-Florentino M, Pérez-García M, Ávila-Ríos S, Hurtado JM, Herrera-Nájera C, Núñez-Contreras J, Sarquiz-Martínez B, García-Arias V, Santiago-Mauricio M, Martínez-Miguel B, Isa P, Wong-Chew RM, Jiménez-Corona ME, López S, Arias CF. 2022. Dominance of three sublineages of the SARS-CoV-2 Delta variant in Mexico. Microbiol Spectr. 10(2):e0224021. doi: 10.1128/spectrum.02240-21.

188. Aguilera-Flores C, López T, Zamudio F, Sandoval-Jaime C, Pérezc EI, López S, DuBois RM, Arias CF, 2022. The capsid precursor protein of astrovirus VA1 is proteolytically processed intracellularly. J Virol. 2022 Jun 28:e0066522. doi: 10.1128/jvi.00665-22.

189. Delgado-Cunningham K; López .; Khatib F; Arias CF; DuBois RM. 2022. Structure of the divergent human astrovirus MLB capsid spike. Aceptado. Structure

190. Hernández-Terán A, GarciaDiego P, Villanueva-Reza M, Boukadida C, Taboada B, Porras E, Ahumada-Topete V, Tapia Diaz K, Matias-Florentino M, Pérez-García M, Ávila-Rios S, Mejía-Nepomuceno F, Serna-Muñoz R, Juárez-Hernández F, Jiménez-Corona ME, Becerril-VargasE, Barreto O, Martínez-Orozco JA, Pérez-Padilla R, Arias CF, Vázquez-Pérez JA. 2022. Clinical and virological features of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants in vaccinated and unvaccinated patients in Mexico City. Aceptado en Vaccines

191. Iša P, Taboada B, Rodrigo García-López1 ,Celia Boukadida2, José Ernesto 4 Ramírez-González3, Joel Armando Vázquez-Pérez4, Alejandra Hernández-Terán4, José 5 Ángel Romero-Espinoza4, José Esteban Muñoz-Medina5, Concepción Grajales-Muñiz5, 6 Alma Rincón-Rubio2, Margarita Matías-Florentino2, Alejandro Sanchez-Flores6, Edgar 7 Mendieta-Condado3, Gisela Barrera-Badillo3, Susana López1, Lucía Hernández-Rivas3, 8 Irma López-Martínez3, Santiago Ávila-Ríos2, Carlos F. Arias. 2022. Metagenomic analysis reveals differences in the co-occurrence and abundance of viral 1 species in SARS-CoV-2 patients with different severity of disease. Aceptado en BMC Infectious diseases.

192. Castelán-Sánchez HG, Delaye L, Inward RPD, Dellicour S, Gutierrez B, Martinez de la Vina N, Pybus OG, de Anda-Jáuregui G , Guzmán P, Flores-Garrido M, Fontanelli O, Hernández-Rosales M, Meneses A, Olmedo-Alvarez G, Herrera-Estrella A, Boukadida C, Sanchez-Flores A, Muñoz-Medina JE, Comas-García A, Gómez-Gil B, Zárate S, Taboada B, López S, Arias CF, Kraemer MUG, Lazcano A, Escalera-Zamudio M. 2022. Comparing the evolutionary dynamics of predominant SARS-CoV-2 virus lineages co-circulating in Mexico. Enviado a Nature Communications.

193. Moreno-Contreras J, Sánchez-Tacuba L, Arias CF, López S. 2022. Mature rotavirus particles contain equivalent amounts of 7meGpppGcap and noncapped viral positive-sense RNAs. bioRxiv. doi: https://doi.org/10.1101/2022.06.03.494783

194. Diversity and dynamics of the fecal and oropharyngeal eukaryotic virome of healthy infants Rivera-Gutiérrez X, Morán P, Taboada B, Serrano-Vázquez A, Iša P, Rojas-Velázquez L, Pérez-Juárez H, López S, Torres J, Ximénez C, Arias CF. Enviado a Scientific Reports

Circuito de Posgrado, Ciudad Universitaria
Alcaldía Coyoacán, C.P. 04510, México, CDMX

55 5623 7006
mdcbq@posgrado.unam.mx