Control del Metabolismo: Bases Moleculares Reguladoras del Epigenoma y la Estructura Nuclear.
1. Aspectos moleculares y epigenéticos que controlan el reloj circadiano en condiciones de salud y enfermedad: cáncer, neurodegeneración o diabetes y obesidad.
2. Regulación metabólica de la arquitectura nuclear: ritmos circadianos y la estructura 3D del genoma.
3. Control epigenético de la diferenciación de células troncales y su relación con la reprogramación metabólica.

Publicaciones

1. Escalante-Covarrubias, Q; Mendoza-Viveros, L; González-Suárez, M; Sitten-Olea, R; Velázquez-Villegas, L.A.; Becerril-Pérez, F; Pacheco-Bernal, I; Carreño-Vázquez, E; Mass-Sánchez, P; Bustamante-Zepeda, M; Orozco-Solis, R; Aguilar-Arnal, L (corr auth). Time-of-day defines NAD+ efficacy to treat diet-induced metabolic disease by synchronizing the hepatic clock in mice. Nature Communications 14, 1685. DOI: 10.1038/s41467-023-37286-2. (IF 17.4). 2023

2. Mendoza-Viveros, L; Marmolejo-Gutierrez, C; Cid-Castro, C; Escalante-Covarrubias, Q; Montellier, E; Carreño-Vázquez, E; Noriega, L.G.; Velázquez-Villegas, L.A.; Tovar, A.R.; Sassone-Corsi, P; Aguilar-Arnal, L; Orozco-Solis, R.
Astrocytic circadian clock control of energy expenditure by transcriptional stress responses in the Ventromedial Hypothalamus. Glia 1– 22. DOI: 10.1002/glia.24360 (IF 8.1) 2023

3. Ahmed, A; Syed, J; Wang, X; Chi, L; Perez-Romero, C, Lee, D; Escalante-Covarrubias, Q; Yang, J; Kocaqi, E; Ishimura, A; Suzuki, T; Aguilar-Arnal, L; Bryan Gonzales, G; Kim K-H;, Delgado-Olguín, P. KDM8 epigenetically controls cardiac metabolism to prevent initiation of dilated cardiomyopathy. Nature Cardiovascular Research, 2, 174-191 DOI: 10.1038/s44161-023-00214-0 IF TBA June 2023
Este artículo se comenta en: Bakshi, S., Wende, A.R. KDM8 prevents heart failure by controlling cardiac metabolism. Nature Cardiovascular Research 2, 106–107

4. Nuñez-Olvera, S.I.; Aguilar-Arnal, L.; Cisneros-Villanueva, M; Hidalgo-Miranda, A; Marchat, L.A.; y Salinas-Vera, Y.M; Ramos-Payán, R; Pérez-Plasencia, C.; Carlos-Reyes, A.; Puente-Rivera, J.; López-Camarillo, C. Breast cancer cells reprogram the oncogenic lncRNAs/mRNAs coexpression networks in three-dimensional microenvironment.
Cells. 11(21):3458. DOI: 10.3390/cells11213458 IF 7.7 2022

5. Sánchez-Ramírez, E, Ung, TPL; Alarcón del Carmen; A; Del Toro-Rios, X; Fajardo-Orduña, GR; Noriega, LG; Cortés-Morales, V.A.; Tovar, AR; Montesinos, JJ; Orozco-Solis, R; Stringari, C; Aguilar-Arnal, L (corr-auth) Coordinated metabolic transitions and gene expression by NAD+ during adipogenesis. Journal of Cell Biology 221 (12): e202111137. DOI: 10.1083/jcb.202111137. IF 10.5 2022

6. Orozco-Solis, R. and Aguilar-Arnal, L. Circadian regulation of immunity through epigenetic mechanisms,
Frontiers in Cellular and Infection Microbiology, Mar 13;10:96. doi: 10.3389/fcimb.2020.00096. IF 6,2 2020

7. Pacheco-Bernal, I; Becerril-Perez, F and Aguilar-Arnal, L. (2019). Circadian rhythms in the three-dimensional genome: implications of chromatin interactions for cyclic transcription, Clinical Epigenetics, 11(1):79. IF 7,2 2019

8. Escalante-Covarrubias, Q, and Aguilar-Arnal, L. (2018). Environmental Regulation of Metabolism through the Circadian Clock, Current Opinion in Toxicology 8, 93-101 2018 IF 4,6

9. Orozco-Solis, R., Montellier E., Aguilar-Arnal L., Sato S, Vawter MP., Bunney B.G., Bunney W.E., Sassone-Corsi P., A Circadian Genomic Signature Common to Ketamine and Sleep Deprivation in the Anterior Cingulate Cortex (2017) Biological Psychiatry. 82(5), 351-360. IF 10.6 2017
Este artículo se comenta en: Morgan, P.T. (2017) Ketamine and Sleep: Bridging the Gap in the Treatment of Depressive Illness. Biological Psychiatry 82(5) 309-311

Circuito de Posgrado, Ciudad Universitaria
Alcaldía Coyoacán, C.P. 04510, México, CDMX

55 5623 7006
mdcbq@posgrado.unam.mx