Contacto
Campos de conocimiento
Bioquímica
Microbiología Molecular
Reconocimiento Molecular y Bioestructura
Líneas de investigación
Modo de acción de las toxinas Cry1
Identificación de Receptores de las toxinas Cry1
Interacción Toxina-Receptor
RNA de Interferencia en Insectos lepidopteros
Publicaciones
Pacheco,S., Gomez,I., Chinas,M., Sanchez,J., Soberon,M., Bravo,A. (2021). Whole Genome Sequencing Analysis of Bacillus thuringiensis GR007 Reveals Multiple Pesticidal Protein Genes. Frontiers in Microbiology, 12, 3268.
Sena da Silva,I.H., Gomez,I., Pacheco,S., Sanchez,J., Zhang,J., Luque Castellane,T.C., Aparecida Desiderio J., Soberon,M., Bravo,A., Polanczyk,R.A. (2021). Bacillus thuringiensis Cry1Ab domain III b-16 is involved in binding to prohibitin which correlates with toxicity against Helicoverpa armigera (Lepidoptera: Noctuidae). Applied and Environmental Microbiology, 87 (2), e01930-20.
Almanza‐Martínez, N., Martínez Díaz, F.S., Flores‐Ramírez, G., Zuñiga‐Navarrete, F., Gómez, I. and Cardona-Félix, C.S. (2020). An ‐amylase‐like protein interacts with PirB toxin from Vibrio parahaemolyticus in digestive tract tissue of white shrimp Litopenaeus vannamei. Aquac Res. 51(9): 3910-14.
Zhang, J., Jin, M., Yang, Y., Liu, L., Yang, Y., Gómez, I., Bravo, A., Soberón, M., Xiao, Y., Liu, K. (2020). The Cadherin Protein Is Not Involved in Susceptibility to Bacillus thuringiensis Cry1Ab or Cry1Fa Toxins in Spodoptera frugiperda. Toxins. 12, 375.
Gomez,I., Ocelotl,J., Sanchez,J., Aguilar-Medel,S., Pena-Chora,G., Lina-Garcia,L., Bravo,A., Soberon,M. (2020). Bacillus thuringiensis Cry1Ab domain III beta-22 mutants with enhanced toxicity to Spodoptera frugiperda (J. E. Smith). Applied and Environmental Microbiology, 86 (22).
Pacheco,S., Quiliche,J.P.J., Gomez,I., Sanchez,J., Soberon,M., Bravo,A. (2020). Rearrangement of N-Terminal alpha-Helices of Bacillus thuringiensis Cry1Ab Toxin Essential for Oligomer Assembly and Toxicity. Toxins (Basel). 12 (10).
Sena da Silva,I.H., Gomez,I., Pacheco,S., Sanchez,J., Zhang,J., Luque Castellane,T.C., Aparecida Desiderio J., Soberon,M., Bravo,A., Polanczyk,R.A. (2020). Bacillus thiringiensis Cry1Ab domain III b-16 is involved in binding to prohibitin which correlates with toxicity against Helicoverpa armigera (lepidoptera:Noctuidae). Applied and Environmental Microbiol. Aceptado.
Peña-Cardeña, A., Grande, R., Sanchez, J., Tabashnik, B.E., Bravo, A., Soberon, M. and Gomez, I. (2018). The C-terminal protoxin domain of Bacillus thuringiensis Cry1Ab toxin has a functional role in binding to GPI-anchored receptors in the insect midgut Journal of Biological Chemistry. 293:20263-20272.
Sena de Silva,I. Gomez,I. Sanchez,J. Martinez de Castro,D.L. Valicente,F.H. Soberon,M. Polanczyk,R.A. Bravo,A. 2018. Identification of midgut membrane proteins from different instars of Helicoverpa armigera (Lepidoptera: Noctuidae) that bind to Cry1Ac toxin PLoS ONE, 13, e0207789.
Gómez, I., Ocelotl, J., Sánchez, J., Lima, C., Martins, E., Rosales-Juárez, A., Aguilar-Medel, S., Abad, A., Dong, H., Monnerat, R., Peña, G., Zhang, J., Nelson, M., Wu, G., Bravo, A., and Soberón, M. (2018) Enhancement of Bacillus thuringiensis Cry1Ab and Cry1Fa toxicity to Spodoptera frugiperda by domain III mutations indicates two limiting steps in toxicity as defined by receptor binding and protein stability. Appl Environ Microbiol. 84:e01393-18.
Pacheco, S., Gómez, I., Sánchez, J., García-Gómez, B.I., Czajkowsky, D.M., Zhang, J., Soberón, M., and Bravo, A. (2018) Helix α-3 inter-molecular salt bridges and conformational changes are essential for toxicity of Bacillus thuringiensis 3D-Cry toxin family. Sci Reports. Jul 9;8(1):10331.
Gómez, I., Rodríguez-Chamorro, D.E., Flores-Ramírez, G., Grande, R., Zúñiga, F., Portugal, F.J., Sánchez, J., Pacheco, S., Bravo, A., and Soberón, M. (2018) Spodoptera frugiperda (J. E. Smith) Aminopeptidase N1 Is a Functional Receptor of the Bacillus thuringiensis Cry1Ca Toxin. Appl Environ Microbiol. Aug 17;84(17)
Wang, Z., Fang, L., Zhou, Z., Pacheco, S., Gómez, I., Song, F., Soberón, M., Zhang, J. and Bravo, A. (2018) Specific binding between Bacillus thuringiensis Cry9Aa and Vip3Aa toxins synergizes their toxicity against Asiatic rice borer (Chilo suppressalis). J Biol Chem. Jul 20;293(29):11447-11458.
Torres-Quintero, M. C., Gómez, I., Pacheco, S., Sánchez, J., Flores, H., Osuna., Mendoza, G., Soberón, M. and Bravo, A. (2018) Engineering Bacillus thuringiensis Cyt1Aa toxin specificity from dipteran to lepidopteran toxicity. Scientific Reports, 8(1):4989.
Soberón, M., Portugal, L., García-Gómez, BI., Sánchez, J., Onofre, J., Gómez, I., Pacheco, S. and Bravo, A. (2018) Cell lines as models for the study of Cry toxins from Bacillus thuringiensis. Insect Biochemistry and Molecular Biology. 93:66-78.
Pacheco, S., Gómez, I., Sánchez, J., Garcia-Gomez, B.I., Soberón, M. and Bravo, A. (2017) Intra-molecular salt bridge in Bacillus thuringiensis Cry4Ba toxin is involved in the stability of helix alpha-3 that is needed for oligomerization and insecticidal activity Applied and Environmental Microbiology, 83, e01515-e01517.
Ocelotl, J., Sanchez, J., Gómez, I., Tabashnik, B. E., Bravo, A. and Soberon, M. (2017) ABCC2 is associated with Bacillus thuringiensis Cry1Ac toxin oligomerization and membrane insertion in diamondback moth Scientific Reports, 7(1):2386.
Onofre, J., Gaytán, M. O., Peña-Cardeña, A., García-Gomez, B.I., Pacheco, S., Gómez, I., Bravo A1, Soberón, M. (2017) Identification of Aminopeptidase-N2 as a Cry2Ab binding protein in Manduca sexta. Peptides. 98:93-98.
Martinez de Castro, D.L., Garcia-Gomez, B.I., Gómez, I., Bravo, A. and Soberon, M. (2017) Identification of Bacillus thuringiensis Cry1AbMod binding-proteins from Spodoptera frugiperda. Peptides. 98:99-105.
