Desarrollo de modelos biológicos y evaluación de drogas antiinflamatorias:
Caracterizacion in vitro de drogas antiinflammatorias, anti-angiogenicas y antibacterianas aisladas a partir de secreciones de rana y validacion de las actividades en modelos in vivo de patologias inflamatorias, como la psoriasis, la dermatitis atopica, la peritonitis o el cancer.

Publicaciones

H-index 11
Cardon S, Sachon E, carlier L, Drujon T, Walmant A, Alemán-Navarro E, Martínez- Osorio V, Guianvarc ́h D, Sagan S, Fleury Y, Marquant R, Piesse C, Rosenstein Y, Auvynet C*, Lacombe L* . “Peptidoglycan potentiates the membrane disrupting effect of the carboxyamidated form of DMS-DA&, a Gram-positive selective antimicrobial peptide isolated from Pachymedusa dacnicolor, accepted in Plos One, Sept 2018 * corresponding author
IF 2.766

Krishnan ML, Van Steenwinckel J, Schang AL, Yan J, Arnadottir J, Le Carpentier T, Csaba Z, Dournaud P, Cipriani S, Auvynet C, Titomanlio L, Pansiot J, Ball G,Boardman JP, Walley AJ, Saxena A, Mirza G, Fleiss B, Edwards AD, Petretto E, Gressens P. “Integrative genomics of microglia implicates DLG4 (PSD95) in the White matter development of preterms infants”. Nat Commun. 2017 Sep 5;8(1):428
IF 12.353

Auvynet C, Beaudesson de Chanville C, Hermand P, Dorgham K, Piesse C, Pouchy C, Carlier L, Poupel L, Barthélémy S, Felouzis V, Lacombe C, Sagan S, Salomón B, Deterre P, Sennlaub F, Combadière C. “ECL1i, d(LGTFLKC), a novel small peptide that specifically inhibits CCL2-dependent migration”, FASEB J 2016, Jun;30(6):2370-81
IF:5.498

Lacombe C, Piesse C, Sagan S, Combadière C, Rosenstein Y, Auvynet C. “Pachymodulin, a new functional formyl peptide receptor 2 peptidic ligand isolated from frog skin has Janus-like immunomodulatory capacities”. J Med Chem. 2015 Feb 12;58(3):1089-99
IF 6.253

Van Steenwinckel J, Auvynet C, Sapienza A, Reaux-Le Goazigo A, Combadière C, Melik Parsadaniantz S. “Stromal cell-derived CCL2 drives neuropathic pain states through myeloid cell infiltration in injured nerve”. Brain Behav Immun. 2015 Mar;45:198-210
IF 6.3

Circuito de Posgrado, Ciudad Universitaria
Alcaldía Coyoacán, C.P. 04510, México, CDMX

55 5623 7006
mdcbq@posgrado.unam.mx