Estudiamos los ritmos circadianos en mamíferos como un modelo para entender los procesos de regulación fisiológica y de la conducta . Estudiamos el núcleo supraquiasmático, sus aferentes y eferentes en la medición del tiempo biológico, su sincronización al ambiente, y la transmisión de la hora al al resto del organismo.
Empleamos cultivo neuronal primario y organotípico, inmunohistoquímica, mapéo de vías neurales, registros electrofisiologicos, imagenología de Ca2+ y Cl- y qPCR.

Publicaciones

75. Rebolledo-Solleiro, D. Ontiveros Araiza, L. Broccoli, L. Hansson, AC. Rocha-Arrieta, L. Aguilar-Roblero, R. Crespo-Ramírez, M. Fuxe, K. Perez de la Mora, M. Dopamine D1 receptor activity is involved in the increased anxiety levels observed in STZ-induced diabetes in rats. Behav. Brain Res. 313: 293–301, http://dx.doi.org/10.1016/j.bbr.2016.06.060, 2016.
76. Aguilar-Roblero, R. Quinto, D. Báez-Ruíz, A. Chávez, JL. Belin, AC. Díaz-Muñoz, M. Michel, S. and Lundkvist, G. Ryanodine-sensitive intracellular Ca2+ channels are involved in the output from the SCN circadian clock. Eur J Neurosci. 44(7): 2504-2514 http://dx.doi.og/10.1111/ejn.13368, 2016
77. Domínguez, M. Aguilar-Roblero, R and González-Mariscal, G. Bilateral lesions of the paraventricular hypothalamic nucleus disrupt nursing behavior in rabbits. Eur J Neurosci. 46(5), 2133–2140 , https://dx.doi.org/10.1111/ejn.13656, 2017
78. Garcia, O.P. & Aguilar-Roblero, R. In Memoriam: René Raúl Drucker-Colín (1937–2017) Sleep Vigilance. https://doi.org/10.1007/s41782-017-0021-x, 2017
79. Bautista, E. Zarco, N. Aguirre-Pineda, N. Lara-Lozano, M. Vergara, P. Gonzalez-Barrios, J.A. Aguilar-Roblero R and Segovia, J. Expression of Gas1 in mouse brair: Release and Role in Neuronal Differentiation. Cellular and Molecular Neurobiology, 38:841–859 https://doi.org/10.1007/s10571-017-0559-0 , 2017
80. Hernández-Pérez OR, Crespo-Ramírez M, Cuza-Ferrer Y, Anias-Calderón J, Zhang L, Roldan-Roldan G, Aguilar-Roblero, R, Borroto-Escuela DO, Fuxe K, Perez de la Mora M. Differential activation of arginine-vasopressin receptor subtypes in the amygdaloid modulation of anxiety in the rat by arginine-vasopressin. Psychopharmacology (Berl), 235 (4):1015-1027 https://doi.org/10.1007/s00213-017-4817-0 , 2018
81. Aguilar-Roblero, R. Mejía-López, A. Cortés-Pedroza, D. Chavez-Juárez, JL. Gutierrez-Monreal, M. Domínguez, G. Vergara,P and Segovia, J. Calcium regulated chloride channel Anoctamin-1 is present in the suprachiasmatic nuclei of rats. NeuroReport, 29(4), 334-339 https://doi.org/10.1097/WNR.0000000000000967, 2018
82. Rivera-Estrada, D, Aguilar-Roblero, R. Alva-Sánchez, C. and Villanueva, I. The homeostatic feeding response to fasting is under chronostatic control, Chronob Int, 35(12), 1680-1688 https://doi.org/10.1080/07420528.2018.1507036, 2018.
83. Aguilar-Roblero, R. How shall we proceed? Biological Rhythm Research 50(1): 10-17 (published on line) https://doi.org/10.1080/09291016.2018.1491269, 2019
84. Herrera-Zamora JM, Castro-Sánchez LA, Reyes-Mendez M, Aguilar-Martinez I, Osuna-López F, Moreno-Galindo EG, Navarro-Polanco RA, Aguilar-Roblero RA, Sánchez-Pastor E, Alamilla J. Development-Dependent Changes in the NR2 Subtype of the N-Methyl-D-Aspartate Receptor in the Suprachiasmatic Nucleus of the Rat. J Biol Rhythms. 34(1), 39–50. https://doi.org/10.1177/0748730418824198, 2019.
85. Aguilar-Roblero, R. and González-Mariscal, G. Behavioral, neuroendocrine, and physiological indicators of the circadian biology of male and female rabbits. Eur J Neurosci. 51:429–453. https://doi.org/10.1111/ejn.14265 , 2020.
86. Alamilla J, Ramiro-Cortés Y, Mejía-López A, Chavez J-L, Rivera DO, Felipe V, Aguilar-Roblero R. Altered Light Sensitivity of Circadian Clock in Shank3+/– Mouse . Front in Neurosci. 15: 604 165. https://www.frontiersin.org/article/10.3389/fnins.2021.604165 , 2021.
87. López-Cervantes M, Quintanar-Stephano A, Alcauter-Solórzano S, Hernández-Pando R, Aguilar-Roblero R, Gasca-Martínez D, Ortíz JJ, Vázquez-Martinez O, Ximenez-Camilli, C, Díaz-Muñoz M. Cerebellar spongiform degeneration is accompanied by metabolic, cellular, and motor disruption in male rats with portacaval anastomosis. J Neurosci Res. 9:2287–2304. https://doi.org/10.1002/jnr.24853 , 2021

Circuito de Posgrado, Ciudad Universitaria
Alcaldía Coyoacán, C.P. 04510, México, CDMX

55 5623 7006
mdcbq@posgrado.unam.mx