Diseño, obtención y evaluación de vacunas de subunidades para administración vía mucosas, basadas en un sistema acarreador (micropartículas) y antígenos recombinantes.

Estudio y caracterización in vivo e in vitro del efecto inmunoestimulante y adyuvante de micropartículas poliméricas para su uso en vacunas.

Aplicaciones biotecnológicas de módulos de unión a carbohidratos.

Publicaciones

1. Barrera-Rosales A, Rodríguez-Sanoja R, Hernández-Pando R, Moreno-Mendieta, S. 2023. The Use of 1. Particulate Systems for Tuberculosis Prophylaxis and Treatment: Opportunities and Challenges. Microorganisms 11:1988; DOI:10.3390/microorganisms11081988. FI 4.5
2. Nathaly Vásquez-Martínez, Daniel Guillén, Silvia Moreno-Mendieta, Pedro Medina-Granados, Rocío Casañas-Pimentel, Eduardo Martín-Martínez, Miguel Morales, Sergio Sánchez, Romina Rodríguez-Sanoja. 2023. In vivo tracing of immunostimulatory raw starch microparticles after mucosal administration. European Journal of Pharmaceutics and Biopharmaceutics 187: 96-106; DOI:10.1016/j.ejpb.2023.04.013. FI 5.46
3. Nathaly Vásquez-Martínez, Daniel Guillén, Silvia Moreno-Mendieta, Sergio Sánchez, Romina Rodríguez-Sanoja. 2023. The Role of Mucoadhesion and Mucopenetration in the Immune Response Induced by Polymer-Based Mucosal Adjuvants. Polymers 15: 1615; DOI:10.3390/polym15071615. FI 4.96
4. Silvia Moreno-Mendieta, Daniel Guillén, Nathaly Vasquez-Martínez, Rogelio Hernández-Pando, Sergio Sánchez, Romina Rodríguez-Sanoja. 2022. Understanding the phagocytosis of particles: The key for rational design of vaccines and therapeutics. Pharmaceutical Research. 10.1007/s11095-022-03301-2
5. Moreno-Mendieta, SA, Barrera-Rosales, A, Mata-Espinosa, D, Barrios-Payán, J, Sánchez, S, Hernández-Pando R, Rodríguez-Sanoja, R. 2019. Raw starch microparticles as BCG adjuvant: Their efficacy depends on the virulence of the infection strains. Vaccine 37:5731-5737. DOI:10.1016/j.vaccine.2019.04.027 ISSN: 0264-410X. FI 3.23
6. Armenta, S, Sánchez-Cuapio, Z, Munguía, ME, Pulido, NO, Farrés, A, Manoutcharian, K, Hernández-Santoyo, A, Moreno-Mendieta, SA, Sánchez, S, Rodríguez-Sanoja, R. 2019. The role of conserved non-aromatic residues in the Lactobacillus amylovorus α-amylase CBM26-starch interaction. International Journal of Biological Macromolecules. 121:829–838. ISSN: 0141-8130. DOI: 10.1016/j.ijbiomac.2018.10.061. FI 3.9
7. Moreno-Mendieta, SA, Barrios-Payán, J, Mata-Espinosa, D, Sánchez, S, Hernández-Pando, R, Rodríguez-Sanoja, R. 2017. Raw starch microparticles have immunostimulant activity in mice vaccinated with BCG and challenged with Mycobacterium tuberculosis. Vaccine 35:5123-5130. ISSN: 0264-410X. DOI: 10.1016/j.vaccine.2017.08.012. FI 3.23
8. Armenta, S, Moreno-Mendieta, SA, Sánchez-Cuapio, Z, Sánchez, S, Rodríguez-Sanoja, R. 2017. Advances in molecular engineering of carbohydrate-binding modules. Proteins: Structure, Function and Bioinformatics. ISSN: 1097-0134. DOI: 10.1002/prot.25327. FI 2.28
9. Moreno-Mendieta, SA, Guillén, D, Hernández-Pando, R, Sánchez, S, Rodríguez-Sanoja, R. 2017. Potential of glucans as vaccine adjuvants: A review of the α-glucans case. Carbohydrate Polymers: 165:103-114. ISSN: 0144-8617. DOI:10.1016/j.carbpol.2017.02.030. FI 4.81
10. Moreno-Mendieta, SA, Guillén, D, Espitia, C, Hernández-Pando, R, Sánchez, S, Rodríguez-Sanoja, R. 2014. A novel antigen-carrier system: The Mycobacterium tuberculosis Acr protein carried by raw starch microparticles. International Journal of Pharmaceutics 474:241-248. ISSN: 0378-5173. DOI. 10.1016/j.ijpharm.2014.07.041. FI 3.650
11. Guillen, D, Moreno-Mendieta, S, Pérez, R, Espitia, C, Sánchez, S, Rodríguez-Sanoja, R. 2014. Starch granules as a vehicle for the oral administration of immobilized antigens, Carbohydrate Polymers. 112:210-215. ISSN: 0144-8617. DOI:10.1016/j.carbpol.2014.05.089. FI 4.81
12. Guillén, D, Moreno-Mendieta, SA, Aguilera, P, Sánchez, S, Farrés, A, Rodríguez-Sanoja, R. 2013. The starch-binding domain as a tool for recombinant protein purification. Applied Microbiology and Biotechnology. 97:4141-4148. ISSN: 1432-0614. DOI 10.1007/s00253-013-4778-0. FI 3.42
13. Moreno-Mendieta, SA, Rocha-Zavaleta, L, Rodríguez-Sanoja, R. 2010. Adjuvants in tuberculosis vaccine development. FEMS Immunology and Medical Microbiology. 58: 75-84. ISSN: 1574-695X. DOI:10.1111/j.1574-695X.2009.00629.x. FI 2.44

Circuito de Posgrado, Ciudad Universitaria
Alcaldía Coyoacán, C.P. 04510, México, CDMX

55 5623 7006
mdcbq@posgrado.unam.mx