A)Estudio molecular del reloj circadiano de los distintos núcleos del hipotálamo y cómo estos son capaces de controlar el balance energético a través de respuestas fisiológicas, metabólicas y celulares.
B)Estudio de la capacidad para generar adipocitos beige activos en individuos con diabetes de tipo 2.
C)Terapias geroprotectivas en un modelo de envejecimiento en ratón
D)Estudio de la regulación del sueño por el reloj molecular de los astrocitos cerebrales.

Publicaciones

(2020) Circadian Regulation of Immunity Through Epigenetic Mechanisms. Frontiers in Cellular and Infection Microbiology. 10(96).
(2018) "Atlas of Circadian Metabolism Reveals System-wide Coordination and Communication between Clocks" Cell FI 28.71
(2017) "A Circadian Genomic Signature Common to Ketamine and Sleep Deprivation in the Cingulate Cortex" Biological Psychiatry FI 11.2
(2016) "Spatial dynamics of SIRT1 dictate the subnuclear distribution of NADH species" PNAS IF 7.06
(2016) "The Circadian Clock in the Ventromedial Hypothalamus Controls Cyclic Energy Expenditure"., Cell Metabolism FI: 17.3
(2015) "Coupling circadian rhythms of metabolism and chromatin remodeling". Diabetes, Obesity and Metabolism FI: 6.2
(2015) "NAD+‐SIRT1 control of H3K4 trimethylation through circadian deacetylation of MLL1". Nat Struct Mol Biol. FI 13.34
(2015) "SIRT1 relays nutritional inputs to the circadian clock through the Sf1 neurons of the ventromedial hypothalamus". Endocrinology FI: 4.16
(2014) "Circadian clock: linking epigenetics to aging". Current Opinion in Genetics & Development FI: 5.78
(2014) "Epigenetic control and the circadian clock: linking metabolism to neuronal responses". Neuroscience. FI: 3.23
(2013) "Reprogramming of the Circadian Clock by Nutritional Challenge” Cell. FI: 28.71
(2012) "Perinatal under‐nutrition alters intestinal alkaline phosphatase and its main transcription factos KLF4 and CDX1 in adult offspring fed a high fat diet" Journal of Nutritional Biochemistry. FI 4.67
(2012) The Time of Metabolism: NAD+, SIRT1, and the Circadian Clock." Cold Spring Harbor Symposia on Quantitative Biology. FI 3.48

Circuito de Posgrado, Ciudad Universitaria
Alcaldía Coyoacán, C.P. 04510, México, CDMX

55 5623 7006
mdcbq@posgrado.unam.mx