Estudios sobre mecanismos bioquímicos implicados en la muerte neuronal durante el envejecimiento y en la Enfermedad de Alzheimer y desarrollo de estrategias de protección neuronal.
Estudios de factores de riesgo metabólico en la Enfermedad de Alzheimer.
Estrategias de recuperación Bioenergética neuronal.

Publicaciones

1.- Ortiz-Matamoros A, Arias C. 2018. Chronic infusion of Wnt7a, Wnt5a and Dkk-1 in the adult hippocampus induces structural synaptic changes and modifies anxiety and memory performance. Brain Res Bull. 139:243-255.
FI: 3.01.
2.- Arias C and Zepeda A. 2018 Do new neurons contribute to functional reorganization after brain damage? Neural Regen Res. 13(12):2083-2084. FI: 2.23
3.- Sánchez-Alegría K, Flores-León M, Avila-Muñoz E, Rodríguez-Corona N, Arias C. 2018. PI3K Signaling in Neurons: A Central Node for the Control of Multiple Functions. Int J Mol Sci. 2018 Nov 23;19(12). pii: E3725. doi: 10.3390/ijms19123725. FI: 3.68
4.- Ortiz-Matamoros A, Arias C. 2019. Differential Changes in the Number and Morphology of the New Neurons after Chronic Infusion of Wnt7a, Wnt5a, and Dkk-1 in the Adult Hippocampus In Vivo. Anat. Rec. doi: 10.1002/ar.24069. FI: 1.37
5.- Flores-León M, Pérez-Domínguez M, González-Barrios R, Arias C. 2019. Palmitic Acid-Induced NAD+ Depletion is Associated with the Reduced Function of SIRT1 and Increased Expression of BACE1 in Hippocampal Neurons. Neurochem Res. 44(7):1745-1754. FI: 2.78.
6.- Navarro-Mabarak C, Mitre-Aguilar IB, Camacho-Carranza R, Arias C, Zentella-Dehesa A, Espinosa-Aguirre JJ. 2019. Role of NF-κB in cytochrome P450 epoxygenases down-regulation during an inflammatory process in astrocytes. Neurochem Int. 129:104499. doi: 10.1016/j.neuint.2019.104499. FI: 3.99
7.- Espino de la Fuente-Muñoz C, Rosas-Lemus M, Moreno-Castilla P, Bermúdez-Rattoni F, Uribe-Carvajal S, Arias C. (2020) Age-Dependent Decline in Synaptic Mitochondrial Function Is Exacerbated in Vulnerable Brain Regions of Female 3xTg-AD Mice.
Int J Mol Sci. 21(22):8727. doi: 10.3390/ijms21228727. FI: 6.2
8.- Espino De la Fuente-Muñoz C, Arias C. (2020) The therapeutic potential of mitochondrial transplantation for the treatment of neurodegenerative disorders. Rev Neurosci. 32(2):203-217. doi: 10.1515/revneuro-2020-0068. FI: 4.35
9.- García-Velázquez L, Arias C. (2021) Differential Regulation of Wnt Signaling Components During Hippocampal Reorganization After Entorhinal Cortex Lesion. Cell Mol Neurobiol. 41(3):537-549. doi: 10.1007/s10571-020-00870-x. FI:4.23
10.- Sánchez-Alegría K, Bastián-Eugenio CE, Vaca L, Arias C. (2021) Palmitic acid induces insulin resistance by a mechanism associated with energy metabolism and calcium entry in neuronal cells. FASEB J. 35(7):e21712. doi: 10.1096/fj.202100243R. FI:5.83
11- Flores-León M, Alcaraz N, Pérez-Domínguez M, Torres-Arciga K, Rebollar-Vega R, De la Rosa-Velázquez IA, Arriaga-Canon C, Herrera LA, Arias C, González-Barrios R. (2021) Transcriptional Profiles Reveal Deregulation of Lipid Metabolism and Inflammatory Pathways in Neurons Exposed to Palmitic Acid. Mol Neurobiol. 58(9):4639-4651. doi: 10.1007/s12035-021-02434-6. FI: 5.68
12.- Tovar-Y-Romo LB, Massieu L, Arias C. (2021) Ricardo Tapia (1940 -2021). J Neurochem. 159(6):1045-1046. doi: 10.1111/jnc.15526. FI: 5.54
13.- García-Velázquez L, López-Carrasco P, Arias C. (2022) Age-dependent changes in Wnt signaling components and synapse number are differentially affected between brain regions. Exp Gerontol. 165:111854. doi: 10.1016/j.exger.2022.111854. FI: 4.25
14.- Sánchez-Alegría K, Arias C. (2023) Functional consequences of brain exposure to saturated fatty acids: From energy metabolism and insulin resistance to neuronal damage. Endocrinol Diabetes Metab. e386. doi: 10.1002/edm2.386. FI: 2.45

Circuito de Posgrado, Ciudad Universitaria
Alcaldía Coyoacán, C.P. 04510, México, CDMX

55 5623 7006
mdcbq@posgrado.unam.mx