1. Mecanismos de inmunidad innata en la amibiasis: papel de las trampas extracelulares de ADN de neutrófilos, eosinófilos y macrófagos, y de los exosomas de la amiba, en protección o patología durante la infección amibiana.
2. Vacunación en mucosas contra la amibiasis: sistemas de liberación de antígenos de la amiba por vía oral (baculovirus, nanopartículas) y análisis de la respuesta inmune en mucosas asociada a la protección contra la amibiasis.
3. Identificación fármacos anti-amibianos.

Publicaciones

1. Aguilar-Diaz H, Nepomuceno T, Carrero JC and León-Sicairos N (León-Sicairos N). Parasiticidal effect of synthetic bovine Lactoferrin peptides on the enteric parasite Giardia intestinalis. Biochemistry and cell Biology, 2017 Feb;95(1):82-90. doi: 10.1139/bcb-2016-0079. FI: 1.895

2. Toledano-Magaña Y, García-Ramos JC, Torres-Gutiérrez C, Vázquez-Gasser C, Esquivel-Sánchez JM, Flores-Alamo M, Ortiz-Frade L, Galindo-Murillo R, Nequiz M, Gudiño-Zayas M, Laclette JP, Carrero JC, Ruiz-Azuara L (Ruiz-Azuara L). Water-Soluble Ruthenium (II) Chiral Heteroleptic Complexes with Amoebicidal in Vitro and in Vivo Activity. J Med Chem. 2017 Feb 9;60(3):899-912. doi: 10.1021/acs.jmedchem.6b00795. PubMed PMID: 28075589. FI: 6.259

3. Drago-Serrano ME, Campos-Rodríguez R, Carrero JC, de la Garza M (Carrero JC and de la Garza M). Lactoferrin: Balancing Ups and Downs of Inflammation Due to Microbial Infections. Int J Mol Sci. 2017 Mar 1;18(3). pii: E501. doi: 10.3390/ijms18030501. Review. PubMed PMID: 28257033. FI: 3.257

4. Villanueva-García C, Gordillo-Chávez EJ, Baños-Ojeda C, Rendón-Franco E, Muñoz-García CI, Carrero JC, Córdoba-Aguilar A, Maravilla P, Galian J, Martínez-Hernández F, Villalobos G (Villalobos G). New Entamoeba group in howler monkeys (Alouatta spp.) associated with parasites of reptiles. Parasitol Res. 2017 Aug;116(8):2341-2346. doi: 10.1007/s00436-017-5519-6. Epub 2017 May 27. FI: 2.329

5. Drago-Serrano ME, Campos-Rodriguez R, Carrero JC, de la Garza M (Carrero JC and de la Garza M). "Lactoferrin and Peptide-derivatives: Antimicrobial Agents with Potential Use in Nonspecific Immunity Modulation". Curr Pharm Des. 2018 Mar 27. doi:10.2174/1381612824666180327155929. [Epub ahead of print] PubMed PMID: 29589540. FI: 2.611

6. Díaz-Godínez C, Fonseca Z, Néquiz M, Laclette JP, Rosales C and Carrero JC (Carrero JC). Entamoeba histolytica trophozoites induce a rapid non-classical NETosis mechanism independent of NOX2-derived reactive oxygen species and PAD4 activity. Front Cell Infect Microbiol. 2018 Jun 5;8:184. doi: 10.3389/fcimb.2018.00184. FI: 4.3

7. Fonseca Z, Díaz-Godínez C, Mora N, Alemán OR, Uribe-Querol E, Carrero JC, Rosales C (Rosales C). Entamoeba histolytica Induce Signaling via Raf/MEK/ERK for Neutrophil Extracellular Trap (NET) Formation. Front Cell Infect Microbiol. 2018 Jul 4;8:226. doi: 10.3389/fcimb.2018.00226. eCollection 2018. PubMed PMID: 30023352; PubMed Central PMCID: PMC6039748. FI: 4.3

8. Díaz-Godínez C, González-Galindo X, Meza-Menchaca T, Bobes RJ, de la Garza M, León-Sicairos N, Carrero JC (Carrero JC). Synthetic bovine lactoferrin peptide Lfampin kills Entamoeba histolytica trophozoites by necrosis and resolves amoebic intracecal infection in mice. Biosci Rep. 2019 Jan 8;39(1). pii: BSR20180850. doi: 10.1042/BSR20180850. Print 2019 Jan 31. PubMed PMID: 30429239; PubMed
Central PMCID: PMC6328891. FI: 2.535

9. Díaz-Godínez C, Carrero JC (Carrero JC). The state of art of neutrophil extracellular traps in protozoan and helminthic infections. Biosci Rep. 2019 Jan 11;39(1). pii:BSR20180916. doi: 10.1042/BSR20180916. Print 2019 Jan 31. Review. PubMed PMID:30498092; PubMed Central PMCID: PMC6328873. FI: 2.535

10. Medina-Reyes EI, Delgado-Buenrostro NL, Déciga-Alcaraz A, Freyre-Fonseca V, Flores-Flores JO, Hernández-Pando R, Barrios-Payán J, Carrero JC, Sánchez-Pérez Y, García-Cuéllar CM, Vaca-Paniagua F and Chirino YI (Chirino YI). Titanium dioxide nanofibers induce angiogenic markers and genomic instability in lung cells leading to a highly dedifferentiated and fibrotic tumor formation in a xenograft model. Environ. Sci.: Nano, 2019, 6, 286-304. https://doi.org/10.1039/C8EN01078A. FI: 7.704

11. Fonseca Z, Uribe-Querol E, Díaz-Godínez C, Carrero JC, Rosales C (Carrero JC and Rosales C). Pathogenic Entamoeba histolytica, but not Entamoeba dispar, induce neutrophil extracellular trap (NET) formation. J Leukoc Biol. 2019 Jun;105(6):1167-1181. doi: 10.1002/JLB.MA0818-309RRR. Epub 2019 Mar 26. PubMed PMID: 30913315. FI: 4.242

12. Martín-Manzo MV, Lara C, Vargas-de-Leon C, Carrero J, Queipo G, Fonseca-Sanchez M, Mejia-Dominguez NR, Kershenobich D, Mummidi S, Zentella-Dehesa A, Hernandez J (Hernandez J). Interaction of Breast Cancer and Insulin Resistance on PD1 and TIM3 Expression in Peripheral Blood CD8 T Cells. Pathol Oncol Res. 2019 Feb 13. 25:1233-1243. doi: 10.1007/s12253-019-00610-7. [Epub ahead of print] PubMed PMID: 30759303. FI: 1.935

13. Román-Carraro FC, Florencio-Martínez LE, Romero-Meza G, Nepomuceno-Mejía T, Carrero JC, Arroyo R, Ortega-López J, Manning-Cela RG, Martínez-Calvillo S (Martínez-Calvillo S). TFIIIB Subunit Bdp1 Participates in RNA Polymerase III Transcription in the Protozoan Parasite Leishmania major. Biomed Res Int. 2019 Apr 1;2019:1425281.doi:10.1155/2019/1425281. eCollection 2019. PubMed PMID: 31058184; PubMed Central. FI: 2.197

14. Vega-Bautista A, de la Garza M, Carrero JC, Campos-Rodríguez R, Godínez-Victoria M, Drago-Serrano ME (Drago-Serrano ME). The Impact of Lactoferrin on the Growth of Intestinal Inhabitant Bacteria. Int J Mol Sci. 2019 Sep 23;20(19). pii: E4707. doi: 10.3390/ijms20194707. Review. PubMed PMID: 31547574; PubMed Central PMCID: PMC6801499. FI: 4.187

15. Carrero JC, Reyes-López M, Serrano-Luna J, Shibayama M, Unzueta J, León-Sicairos N, de la Garza M (de la Garza M). Intestinal amoebiasis: 160 years of its first detection and still remains as a health problem in developing countries. Int J Med Microbiol. 2020 Jan;310(1):151358. doi: 10.1016/j.ijmm.2019.151358. Epub 2019 Sep 19. Review. PubMed PMID: 31587966. FI: 3.362

16. Cedillo-Gutiérrez EL, Hernández-Ayala LF, Torres-Gutiérrez C, Reina M, Flores-Alamo M, Carrero JC, Ugalde-Saldívar VM, Ruiz-Azuara L. Identification of descriptors for structure-activity relationship in ruthenium (II) mixed compounds with antiparasitic activity. Eur J Med Chem. 2020 Jan 22;189:112084. doi: 10.1016/j.ejmech.2020.112084. [Epub ahead of print] PubMed PMID: 32000049. FI: 4.833

17. Díaz-Godínez C, Ontiveros-Rodríguez JC, Ríos-Valencia DG, Herbert-Pucheta JE, Zepeda-Vallejo LG, Carrero JC. Anti-amoebic Activity of Leaf Extracts and Aporphine Alkaloids Obtained from Annona purpurea. Planta Med. 2020 Apr;86(6):425-433. doi:10.1055/a-1111-9566. Epub 2020 Feb 27. PubMed PMID: 32108930. FI: 2.746

18. Daniela Lozano-Amado, Pedro Antonio Ávila-López, Georgina Hernández-Montes, Paola Briseño-Díaz, Miguel Vargas, José-Juan Lopez-Rubio, Julio César Carrero and Rosaura Hernández-Rivas. A class I histone deacetylase is implicated in the encystation of Entamoeba invadens. [published online ahead of print, 2020 Aug 18]. Int J Parasitol. 2020;S0020-7519(20)30234-4. doi:10.1016/j.ijpara.2020.05.014. FI: 3.530

19. Rosales-Reyes R, Garza-Villafuerte P, Vences-Vences D, Aubert DF, Aca-Teutle R, Ortíz-Navarrete VF, Bonifaz LC, Carrero-Sánchez JC, Olivos-García A, Valvano MA and Santos-Preciado JI. Interferon-gamma-activated macrophages infected with Burkholderia cenocepacia process and present bacterial antigens to T-cells by class I and II major histocompatibility complex molecules [published online ahead of print, 2020 Sep 1]. Emerg Microbes Infect. Dec;9(1):2000-2012. doi:10.1080/22221751.2020.1818632. FI: 6.212

20. Elena V. Basiuk, Brian Monroy-Torres, Julio C. Carrero & Vladimir A. Basiuk (Carrero JC and Basiuk WA) (2021) Effects of solvent-free amine functionalization of graphene oxide and nanodiamond on bacterial growth, Fullerenes, Nanotubes and Carbon Nanostructures, 29:1, 58-66, DOI: 10.1080/1536383X.2020.1811235. FI 1.61.

21. Díaz-Godínez, C., Jorge-Rosas, J. F., Néquiz, M., Martínez-Calvillo, S., Laclette, J. P., Rosales, C., & Carrero, J. C. (2021). New Insights on NETosis Induced by Entamoeba histolytica: Dependence on ROS from Amoebas and Extracellular MPO Activity. Antioxidants (Basel, Switzerland), 10(6), 974. https://doi.org/10.3390/antiox10060974. FI 6.312

22. Toledano-Magaña, Y., Flores-Santos, L., Montes de Oca, G., González-Montiel, A., García-Ramos, J. C., Mora, C., Saavedra-Ávila, N. A., Gudiño-Zayas, M., González-Ramírez, L. C., Laclette, J. P., & Carrero, J. C. (2021). Toxicological Evaluations in Macrophages and Mice Acutely and Chronically Exposed to Halloysite Clay Nanotubes Functionalized with Polystyrene. ACS omega, 6(44), 29882–29892. https://doi.org/10.1021/acsomega.1c04367. FI 3.512

23. Carrero, J. C., Curay-Herrera, V., Chacón-Niño, L., Krengel, F., Guzmán-Gutiérrez, S. L., Silva-Miranda, M., González-Ramírez, L. C., Bobes-Ruíz, R., Espitia, C. I., Reyes-Chilpa, R., & Laclette, J. P. (2022). Potent anti-amoebic effects of Ibogaine, Voacangine and the root bark alkaloid fraction of Tabernaemontana arborea. Planta medica, 10.1055/a-1809-1157. Advance online publication. https://doi.org/10.1055/a-1809-1157. FI: 3.352

Circuito de Posgrado, Ciudad Universitaria
Alcaldía Coyoacán, C.P. 04510, México, CDMX

55 5623 7006
mdcbq@posgrado.unam.mx