Contacto
Campos de conocimiento
Neurobiología
Líneas de investigación
Las líneas de investigación son:
Identificación de biomarcadores de efecto del estrés para detectar riesgo a desarrollar adicción a los alimentos y obesidad.
Participación de la vía del AMPc en la expresión de TRH del núcleo paraventricular del hipotálamo, el núcleo accumbens y el hipocampo y su relación con la regulación de la conducta alimentaria y desórdenes afectivos.
Estudio comparativo del efecto de la anorexia y de la restricción alimentaria sobre el eje tiroideo y la activación de neuron
Publicaciones
1. García-Luna C., Soberanes-Chávez P., de Gortari P. Impaired hypothalamic CART expression in LHA and PVN nuclei of dehydration-induced anorexic rats. J of Neuroendocrinol, e12541, 2017. ISSN ONLINE: 1365-2826, ISSN IMPRESO: 0953-8194 doi: 10.1111/jne.12541. FACTOR IMPACTO: 3.47
2. Alcántara-Alonso V., Alvarez-Salas E., Matamoros-Trejo G., de Gortari P. Intrauterine Zn deficiency favors TRH-increasing effects on TSH serum levels and induces subclinical hypothyroidism in weaned rats. Nutrients, 9: 1139, 2017. ISSN 2072-6643. doi:10.3390/nu9101139. FACTOR IMPACTO: 3.55
3.Alcántara-Alonso V., Panetta P., de Gortari P. Grammatopoulos D.K. Corticotropin releasing hormone as the homeostatic rheostat of fetus-maternal symbiosis and developmental programming in uterus and neonatal life. Front in Endocrinol, 8:1-10, 2017 ISSN: 1664-2392 doi: 10.3389/fendo.2017.00161. FACTOR IMPACTO: 3.67
4.Alcántara-Alonso V., Amaya M.I., de Gortari P. Altered functionality of the corticotrophin-releasing factor receptor-2 in the hypothalamic paraventricular nucleus of hyperphagic maternally separated rats. Neuropeptides, 63:75-82, 2017, ISSN: 0143-4179. dx.doi.org/10.1016/j.npep.2017.01.006. FACTOR IMPACTO: 2.48
5.Valdés-Moreno M., Alcántara-Alonso V., Mengod G., Estrada-Camarena E, Amaya M.I., Matamoros-Trejo G., de Gortari P. Phosphodiesterase-7 inhibition affects accumbal and hypothalamic TRH expression, feeding and anxiety behavior of rats. Behav Brain Res, 319:165-173, 2017 ISSN: 0166-4328. FACTOR IMPACTO: 3.0
6.García-Luna C., Soberanes-Chávez P., de Gortari P. Prepuberal light phase feeding induces neuroendocrine alterations in adult rats. J Endocrinol, 232:15-28, 2017 ISSN: 0022-0795, DOI:10.1530/JOE-16-0402. FACTOR IMPACTO: 4.7
7.Puga L., Alcántara-Alonso V., Coffeen U., Jaimes O., de Gortari P. TRH injected into the nucleus accumbens shell releases dopamine and reduces feeding motivation in rats. Behav Brain Res, 306:128-136, 2016. ISSN: 0166-4328, DOI:10.1016/j.bbr.2016.03.031.FACTOR IMPACTO: 3.0
8.Alvarez-Salas E., Mengod G., García-Luna C., Soberanes-Chávez P., Matamoros G., de Gortari P. MCT8 and TRH co-expression throughout the hypothalamic paraventricular nucleus is modified by dehydration-induced anorexia in rats. Neuropeptides 56:33-40, 2016. ISSN: 0143-4179, DOI 10.1016/j.npep. 2015.11.001. FACTOR IMPACTO: 2.48
9.Alvarez-Salas E., Alcántara-Alonso V., Matamoros-Trejo G., Vargas, M.A., Morales-Mulia M., de Gortari P. Mediobasal hypothalamic and adenohypophyseal TRH-degrading enzyme (PPII) is down-regulated by Zinc deficiency. Int. J. Develop. Neurosci., 46:115-124, 2015. ISSN: 0736-5748, DOI:10.1016/j.ijdevneu. 2015.08.001. FACTOR IMPACTO: 2.025
10.Aréchiga F., Alvarez-Salas E., Matamoros-Trejo G., Amaya M.I., García-Luna C. de Gortari P. Pro-TRH and pro-CRF expression in paraventricular nucleus of small litter-reared fasted adult rats. J. Endocrinol., 221: 1-13, 2014. ISSN: 0022-0795. DOI: 10.1530/JOE-13-0458.FACTOR IMPACTO: 4.7
11.Morales-Mulia M., de Gortari P., Amaya M.I., Méndez M. “Acute ethanol administration differentially alters Enkephalinase and Aminopeptidase N activity and mRNA levels in regions of the nigrostriatal pathway”. J. Mol. Neurosci., 49: 289-300, 2013. FACTOR IMPACTO: 2.89
12.León-Olea M., Miller-Pérez C., Sánchez-Islas E., Mendoza-Sotelo J, Garduño-Gutiérrez R, de Gortari P., Amaya M.I., The nociceptin/orphanin FQ-like opioid peptide in nervous periesophageal ganglia of land snail Helix aspersa. Brain Res., 1505: 22-46, 2013. FACTOR IMPACTO: 2.72
13.Soberanes-Chávez P., de Gortari P., López-Rubalcava C., Cruz S. Exposure to toluene and stress during pregnancy impairs pups' growth and dams' lactation. Neurotoxicology and Teratology, 40: 9-16, 2013. FACTOR IMPACTO:2.76
CAPITULOS DE LIBRO INTERNACIONALES
1. P. de Gortari., E. Alvarez-Salas, C. García-Luna, P. Soberanes-Chávez, M. Valdés, D. Pineda. The relevance of animal models of anorexia: focus on depression and anxiety. In ANOREXIA. SM group Open Access eBooks, ISBN: 978-1-944685-08-9, Dover, DE, USA, 2016.
2. P. de Gortari., E. Alvarez-Salas, L. Jaimes-Hoy. Inhibited TRHergic pathway of amygdala and insular cortex may participate in high anxiety levels and decreased food intake of dehydrated-induced anorexic rats. In HORMONES AND BEHAVIOR. Davis Simonsen (Ed). Nova Science Publishers, ISBN: 978-1-62417-767-5, Hauppauge,NY, pp: 67-84, 2013.
