1. Mechanisms involved in the development of chronic kidney disease (CKD) induced by a period of acute kidney injury (AKI).
2. Aldosterone and receptor mineralocorticoids in the pathophysiology of renal diseases.
3. Molecular Physiology and pathophysiology of renal heat shock proteins.
4. New biomarkers for detecting kidney damage.
5. Searching of the actions of serpina A3 in the kidney diseases of different
etiologies
5. Translational Research.

Publicaciones

1) Sánchez-Navarro A, Martínez-Rojas MA, Albarrán-Godinez A, Pérez-Villalva R, Auwerx J, de la Cruz A, Noriega LG, Rosetti F , and Bobadilla NA. Autor Corresponsal: Bobadilla NA. Transient Sirtuin 7 deficiency reduces inflammation and tubular damage induced by an episode of acute kidney injury. Int J Mol Sci Int J Mol Sci 23, 2573, 2022.

2) Sánchez-Navarro A, Murillo-de-Ozores AR, Pérez-Villalva R, Linares N, Carbajal-Contreras H, Flores ME, Gamba G, Castañeda-Bueno M, and Bobadilla NA: Autor Corresponsal: Bobadilla NA. Transient response of serpinA3 during cellular stress. FASEB J 36(3):e22190.2022.
3) Catalán R, Jiménez-Ceja JV, Rincón-Pedrero R, Olivas-Martínez A, Martínez-Rueda AJ, Bazúa-Valenti S, Carrillo-Pérez DL, Grajeda-Medina LI, García-Juárez I, Vilatobá M, Ortega-Trejo JA, Pérez-Villalva R, Bobadilla NA, Moreno E, Gamba G. Factors Associated with Development of Acute Kidney Injury After Liver Transplantation. En prensa Rev Invest Clin. 2022.
4) Sánchez-Navarro A, Martínez-Rojas MA, Caldiño-Bohn R.I. Pérez-Villalva R, Zambrano E,. Castro-Rodríguez DC, and Bobadilla NA. Autor Corresponsal: Bobadilla NA Early riggers of moderately high-fat diet-induced kidney damage. Physiol Rep 9:e14937, 1-13, 2021.
5) Sánchez-Navarro A, Pérez-Villalva R, Murillo-de-Ozores AR, Martínez MA, Rodríguez‐Aguilera JR, Ortega E, Castañeda-Bueno M, Gamba G, Recillas-Targa F, Bobadilla NA. Autor Corresponsal: Bobadilla NA. Vegfa promoter gene hypermethylation at HIF1α binding site is an early contributor to CKD progression after renal ischemia. Sci Rep 22;11(1):8769, 2021
6) Sanchéz-Navarro A, González-Soria I, and Bobadilla NA. Autor Corresponsal: Bobadilla NA. Serpins in health and Disease: contribution of serpinA3. Am J Physiol – Cell Physiol 320: C106–C118, 2021.
7) Ostrosky-Frid M, Chavez-Canales M, Zhang J, Andrukova O, Argaiz E, Lerdo de Tejada F, Murillo-de-Ozores A, Sanchez-Navarro A, Rojas-Vega L, Bobadilla N.A, Vazquez N, Castaneda-Bueno M, Alessi D, Gerardo Gamba: Role of KLHL3 and dietary K+ in regulating KS-WNK1 expression. Am J Physiol-Renal Physiol 1;320(5):F734-F747, 2021.
8) Lima-Posada I and Bobadilla NA. Understanding the opposite effects of sex hormones in mediating renal injury. Autor Corresponsal: Bobadilla NA. Nephrology (Carlton). 26:217-226, 2021. doi: 10.1111/nep.13806.
9) Díaz L, Zambrano E, Flores ME, Contreras M, Crispín JC, Alemán G, Bravo C, Armenta A, Valdés VJ, Tovar A, Gamba G, Barrios-Payán J , and Bobadilla NA. Autor Corresponsal: Bobadilla NA. I. Ethical Considerations in Animal Research: The principle of 3R´s. Rev Inv Clin 73(4): 199-209, 2021.
10) Ortega-Trejo JA, Pérez-Villalva R, Arreola-Guerra JM, Ramírez V, Sifuentes-Osornio J, and Bobadilla NA. Autor Corresponsal: Bobadilla NA. Fosfomycin trometamol administration enhances cyclosporine nephrotoxicity. Antibiotics, 9:720, 1-14, 2020.
11) Martínez-Rojas MA, Vega-Vega O, Bobadilla NA. Autor Corresponsal: Bobadilla NA. Is the kidney a target of SARS-CoV-2?" Am J Physiol-Renal Physiol. 318(6): F454-F462, 2020. ISSN: 1522-1466.
12) García-Ortuño LE, Barrera-Chimal J, Pérez-Villalva R, Ortega-Trejo JA, Luna-Bolaños E, Lima-Posada I, Sánchez Navarro A, Reyes-Castro L, Gamba G, Zambrano E, and Bobadilla NA. Autor Corresponsal: Bobadilla NA. Resilience to acute kidney injury in offspring of maternal protein restriction. Am J Physiol-Renal Physiol. 317(6):F1637-F1648, 2019. ISSN: 1522-1466.
13) Sánchez-Navarro A, Pérez-Villalva R, Mejía-Vilet JM, Carrillo-Pérez DL, Gamba G, Bobadilla NA. Autor Corresponsal: Bobadilla NA. SerpinA3 in the Early Recognition of Acute Kidney Injury to Chronic Kidney Disease (CKD) transition in the rat and its Potentiality in the Recognition of Patients with CKD. Sci Rep. 9(1):10350, 2019. ISSN: 2045-2322.

14) Morales-Buenrostro LE, Ortega-Trejo JA, Pérez-Villalva R, Marino LA, González-Bobadilla Y, Juárez H, Zamora-Mejía FM, González N, Espinoza R, Barrera-Chimal J and Bobadilla NA. Autor Corresponsal: Bobadilla NA. Spironolactone reduces oxidative stress in living donor kidney transplantation: a randomiz ISSN 1522-1466.ed controlled trial. Am J Physiol-Renal Physiol. 317(3): F519-F528, 2019. ISSN: 1522-1466

15) Barrera-Chimal J, Rocha L., Amador-Martínez I, Pérez-Villalva R, Gonzalez R., Cortés-González C, Uribe N, Berman N, Gamba G, Bobadilla N.A. Autor Corresponsal: Bobadilla NA. Delayed spironolactone administration prevents the transition from acute kidney injury to chronic kidney disease through improving renal inflammation. Nephrol Dial Transpl 34(5):794-801, 2019. ISSN: 0931-0509,

16) Amador-Martínez I, Pérez-Villalva R, Uribe N, Cortés-González CC, Bobadilla NA, Barrrera-Chimal J. Reduced endothelial nitric oxide synthase activation contributes to cardiovascular injury during chronic kidney disease progression. Am J Physiol-Renal Physiol 317(2):F275-F285, 2019. ISSN: 1522-1466. ISSN: 1522-1466

17) Lima-Posada I, Fontana F, Pérez-Villalva R, Berman-Parks N and Bobadilla NA. Autor Corresponsal: Bobadilla NA. Pirfenidone prevents Acute Kidney Injury in the Rat. BMC Nephrol. 20(1):158, 2019. ISSN: 1471-2369.

18) García-Ortuño LE, Bobadilla NA. Autor Corresponsal: Bobadilla NA. Integrative view of the mechanism that induced acute kidney injury and its trasition to chronic kidney disease. Rev Invest Clin 70:261-268, 2018. ISSN: 0034-8376.

19) Bazua-Valenti S, Rojas-Vega L, Castañeda-Bueno M, Barrera-Chimal J, Bautista R, Cervantes-Pérez LG, Vázquez N, Plata C, Murillo-de-Ozores AR., González-Mariscal , Ellison DH, Riccardi N, Bobadilla NA, Gamba G. The Calcium-Sensing Receptor Increases Activity of the Renal NCC through the WNK4-SPAK Pathway. J Am Soc Nephrol 29(7):1838-1848, 2018. ISSN: 1046-6673.

20) Torre-Villalvazo I, Cervantes-Perez LG, Noriega LG, Jimenez JV, Uribe N, Chavez-Canales M, Tovar-Palacio C, Marfil-Garza BA, Torres N, Bobadilla NA, Tovar AR, Gamba G. Inactivation of SPAK kinase reduces body weight gain in mice fed a High-fat diet by improving energy expenditure and insulin sensitivity. Am J Physiol-Endocrinol Metab 314(1):E53-E65, 2018. ISSN: 0193-1849.

21) Moreno E, Gayosso JA, Montejano JR, Almaguer G, Vázquez N, Cruz C, Mercado A, Bobadilla NA, Gamba G, Sierra A, Ramírez V Geraniin is a diuretic by inhibiting the Na+:K+:2Cl- cotransporter, NKCC2. Am J Physiol-Renal Physiol 314(2):F240-F250, 2018. ISSN: 1522-1466.

22) Cervantes-Pérez LG, Castañeda-Bueno M, Jiménez JV, Vázquez N, Rojas-Vega L, Alessi D, Bobadilla N.A., Gamba G: Disruption of the with no lysine kinase-STE20-proline alanine-rich kinase pathway reduces the hypertension induced by angiotensin II. J Hypertens 36(2):361-367, 2018. ISSN:1473-5598

23) Lima-Posada I, Portas-Cortés C, Pérez-Villalva R, Fontana F, Rodríguez-Romo R, Prieto R, Sánchez-Navarro A, Rodríguez-González GL, Gamba G, Zambrano E and Bobadilla NA. Autor Corresponsal: Bobadilla NA. Gender Differences in the Acute Kidney Injury to Chronic Kidney Disease Transition. Sci Rep 25;7(1):12270, 2017. ISSN: 2045-2322.

24) Medeiros, Velásquez-Jones L, Hernández AM, Ramón-García G, Valverde S, Fuentes Y, Vargas A, Patiño M, Pérez-Villalva R, Ortega-Trejo JA, Barrera-Chimal J, Bobadilla NA. Autor Corresponsal: Bobadilla NA. Randomized Controlled Trial of Mineralocorticoid Receptor Blockade in Children with Chronic Kidney Allograft Nephropathy. Clin J Am Soc Nephrol 12(8):1291-1300, 2017. ISSN: 1555-9041.

25) Pérez-Villalva R, Barrera-Chimal J, Aguilar-Carrasco JC, Lima-Posada I, Cruz C, Ramírez V, González-Bobadilla Y, Uribe N, Trumper L, Bobadilla NA. Autor Corresponsal: Bobadilla NA. Hsp72 is an early biomarker to detect cisplatin and acetaminophen nephrotoxicity. Biomarkers 22(6):548-556, 2017. ISSN: 1354-750X.

26) Lattenist L, Lechner SM, Messaoudi S, Le Mercier A, El Moghrabi S, Prince S, Bobadilla NA, Kolkhof P, Jaisser F, Barrera-Chimal J. Nonsteroidal Mineralocorticoid Receptor Antagonist Finerenone Protects Against Acute Kidney Injury-Mediated Chronic Kidney Disease: Role of Oxidative Stress. Hypertension. 69(5):870-878, 2017. ISSN: 0194-911X.

27) Barba-Navarro R, Tapia-Silva M, Garza-Garcia C, López-Giacoman S, Melgoza-Toral I, Vázquez-Rangel A, Bazúa-Valenti S, Bobadilla N, Wasung de Lay M, Baranda F, Chawla LS, Gamba G, Madero M. The Effect of Spironolactone on Acute Kidney Injury After Cardiac Surgery: A Randomized, Placebo-Controlled Trial. Am J Kidney Dis 269(2):192-199, 2017. ISSN: 0272-6386

28) Valenzuela-García P, Bobadilla N.A., Ramírez-González V, León-Villanueva A, Lares-Asseff I, Valdez-Ortíz A, Medina-Godoy S: Antihypertensive effect of protein hydrolysate from Azufrado beans in spontaneously hypertensive rats. Cereal Chem 94(1):117-122, 2017. ISSN: 0009-0352.

Circuito de Posgrado, Ciudad Universitaria
Alcaldía Coyoacán, C.P. 04510, México, CDMX

55 5623 7006
mdcbq@posgrado.unam.mx