Estudio de los factores asociados a la resistencia y susceptibilidad a la cisticercosis: factores del
parásito, del hospedero y de la relación hospedero-parásito
Estudio de las propiedades inmunomoduladoras de moléculas de origen infeccioso y no infeccioso:
a) potenciación de la respuesta inmune para la optimización de vacunas
b) Control de la inflamación en procesos autoinmunes y en procesos inflamatorios de bajo grado
Control de la neuroinflamación

Publicaciones

1. Dunia Rassy, Raúl J.Bobes, Gabriela Rosas, Victor H. Anaya, Klaus Brehm, Beatriz Hernández, Jacquelynne Cervantes, Saúl Pedraza, Julio Morales, Nelly Villalobos, Aline S. de Aluja, Juan P. Laclette, Caris M. Nunes, Germano F. Biondi, Gladis Fragoso, Marisela Hernández, Edda Sciutto. Characterization of S3Pvac anti-cysticercosis vaccine components: implications for the development of an anti-cestodiasis vaccine. Plos One 2010 5(6): e11287 4.351. FI 3.23

2. Julio Morales, Aline S. de Aluja, Jose Juan Martínez, Marisela Hernández, Gabriela Rosas, Nelly Villalobos, Beatriz Hernández, Abel Blancas, Karen Manoutcharian, Goar Gevorkian, Jacquelynne Cervantes, Alicia Díaz, Agnes Fleury, Gladis Fragoso, Carlos Larralde, Edda Sciutto Recombinant S3Pvac-phage anticysticercosis vaccine: simultaneous protection against cysticercosis and hydatid disease in rural pigs. Vet. Parasitol. 2011 Feb 28;176(1):53-8. FI 2.46

3. Aluja A. S. de, Herrera G. S., Hernández M., Plancarte A., Fragoso G., Sciutto E. Limits of the therapeutic properties of the synthetic s3pvac anti-cysticercosis vaccine Vet. Parasitol. 19;177(1-2):90-6. FI 2.46

4. Michelet L, Fleury A, Sciutto E, Kendjo E, Fragoso G, Paris L, Bouteille B. Human neurocysticercosis: comparison of different diagnostic tests using cerebrospinal fluid. J Clin Microbiol. 2011 Jan;49(1):195-200. FI 3.99

5. Sciutto E, Fragoso G, Larralde C. Taenia crassiceps as a model for Taenia solium and the S3Pvac vaccine. Parasite Immunol. 2011 Jan;33(1):79-80. FI 2.14

6. Quet F, Preux PM, Huerta M, Ramirez R, Abad T, Fragoso G, Morales J, Sciutto E, Fleury A. Determining the burden of neurological disorders in populations living in tropical areas: who would be questioned? Lessons from a mexican rural community Neuroepidemiology. 2011;36(3):194-203. FI 2.558

7. Fragoso G, Esquivel-Guadarrama F, Santana MA, Bobes RJ, Hernández B, Cervantes J, Segura R, Goldbaum FA, Sciutto E, Rosas G. HETEROLOGOUS PRIME-BOOST ORAL IMMUNIZATION WITH GK-1 PEPTIDE FROM Taenia crassiceps CYSTICERCI INDUCES PROTECTIVE IMMUNITY. Clin Vaccine Immunol. 2011 Jul;18(7):1067-76. FI. 2.47

8. Ramirez-Aquino R, Radovanovic I, Fortin A, Sciutto-Conde E, Fragoso-González G, Gros P, Aguilar-Delfin I. Identification of loci controlling restriction of parasite growth in experimental Taenia crassiceps cysticercosis. PLoS Negl Trop Dis. 2011 Dec;5(12):e1435. FI: 4.446

9. Betancourt MA, de Aluja AS, Sciutto E, Hernández M, Bobes RJ, Rosas G, Hernández B, Fragoso G, Hallal-Calleros C, Aguilar L, Flores-Peréz I. Effective protection induced by three different versions of the porcine S3Pvac anticysticercosis vaccine against rabbit experimental Taenia pisiformis cysticercosis. Vaccine. 2012 Feb 18.
FI.3.624

10. Fragoso G, Bobes RJ, Espinoza B, Martínez ML, Pérez-Morales D, Rosas G, Sciutto E, Laclette JP. Changes in cyst's nuclear chromatin resulting after experimental manipulation of Taenia crassiceps mice infections: Biological implications. Exp Parasitol. 2012 Feb 10. FI. 1.638

11. Cárdenas G, Valdez R, Sáenz B, Bottasso O, Fragoso G, Sciutto E, Romano MC, Fleury A. Impact of Taenia solium neurocysticercosis upon endocrine status and its relation with immuno-inflammatory parameters. Int J Parasitol. 2012 Feb;42(2):171-6. FI: 3.872

12. Adalid-Peralta L, Fragoso G, Fleury A, Sciutto E. Mechanisms underlying the induction of regulatory T cells and its relevance in the adaptive immune response in parasitic infections. Int J Biol Sci. 2011;7(9):1412-26. FI: 4.5

13. Adalid-Peralta L, Fleury A, García-Ibarra TM, Hernández M, Parkhouse M, Crispín JC, Voltaire-Proaño J, Cárdenas G, Fragoso G, Sciutto E. Human neurocysticercosis: in vivo expansion of peripheral regulatory T cells and their recruitment in the central nervous system. J Parasitol. 2012 Feb;98(1):142-8. FI 1.227

14. Sáenz B, Fleury A, Chavarría A, Hernández M, Crispin JC, Vargas-Rojas MI, Fragoso G, Sciutto E. Neurocysticercosis: local and systemic immune-inflammatory features related to severity. Med Microbiol Immunol. 2012 Feb;201(1):73-80. FI 3.038

15. Rosales-Mendoza S, Govea-Alonso DO, Monreal-Escalante E, Fragoso G, Sciutto E Developing plant-based vaccines against neglected tropical diseases: Where are we? Vaccine. 2012 Dec 17;31(1):40-8. FI.3.624

16. Sáenz B, Hernandez-Pando R, Fragoso G, Bottasso O, Cárdenas G The dual face of central nervous system tuberculosis: a new Janus Bifrons? Tuberculosis (Edinb). Tuberculosis (Edinb). 2013 Mar;93(2):130-5 FI 2.71

17. Sciutto E, G Fragoso, M Hernández, G Rosas, J J. Martínez, A Fleury, J Cervantes, A Aluja, and C Larralde.Development of the S3Pvac vaccine against porcine Taenia solium cysticercosis: a historical review. J Parasitol. 2013 Aug;99(4):686-92. . FI 1.227

18. Sciutto E, G Fragoso, M Hernández, G Rosas, J J. Martínez, A Fleury, J Cervantes, A Aluja, and C Larralde Development of the S3Pvac vaccine against murine Taenia crassiceps cysticercosis: a historical review. J. Parasitol. 2013 Aug;99(4):693-702. . FI 1.227

19. Tsai IJ, Zarowiecki M, Holroyd N, Garciarrubio A, Sanchez-Flores A, Brooks KL, Tracey A, Bobes RJ, Fragoso G, Sciutto E, Aslett M, Beasley H, Bennett HM, Cai J, Camicia F, Clark R, Cucher M, De Silva N, Day TA, Deplazes P, Estrada K, Fernández C, Holland PW, Hou J, Hu S, Huckvale T, Hung SS, Kamenetzky L, Keane JA, Kiss F, Koziol U, Lambert O, Liu K, Luo X, Luo Y, Macchiaroli N, Nichol S, Paps J, Parkinson J, Pouchkina-Stantcheva N, Riddiford N, Rosenzvit M, Salinas G, Wasmuth JD, Zamanian M, Zheng Y; The Taenia solium Genome Consortium, Cai X, Soberón X, Olson PD, Laclette JP, Brehm K, Berriman M The genomes of four tapeworm species reveal adaptations to parasitism. Nature. 2013 Apr 4;496(7443):57-63. FI: 41.45

20. Adalid-Peralta L, Arce-Sillas A, Fragoso G, Cárdenas G, Rosetti M, Casanova-Hernández D, Rangel-Escareño C, Uribe-Figueroa L, Fleury A, Sciutto E. Cysticerci drive dendritic cells to promote in vitro and in vivo Tregs differentiation. Clin Dev Immunol. 2013;2013:981468. doi: 10.1155/2013/981468.

21. Segura-Velázquez R, Cervantes J, Acosta E, Sánchez-Betancourt I, Villalobos N, Rodarte LF, Restelli M, Fragoso G, Sciutto E. Influenza vaccine: development of a novel intranasal and subcutaneous recombinant adjuvant. Vaccine. 2013 Aug 20;31(37):4009-16. FI.3.624

22. Sciutto E, Cárdenas G, Adalid-Peralta L, Fragoso G, Larralde C, Fleury A. Human neurocysticercosis: immunological features involved in the host's susceptibility to become infected and to develop disease. Microbes Infect. 2013 Jun;15(6-7):524-30. FI 2.86

23. Fleury A, Garcia E, Hernández M, Carrillo R, Govezensky T, Fragoso G, Sciutto E, Harrison LJ, Parkhouse RM. Neurocysticercosis: HP10 antigen detection is useful for the follow-up of the severe patients. PLoS Negl Trop Dis. 2013;7(3):e2096. doi: 10.1371/journal.pntd.000209. FI: 4.446

24. Palafox-Fonseca H., Gerardo Zúñiga, Raúl José Bobes, Tzipe Govezensky, Daniel Piñero, Laura Texco-Martínez, Agnès Fleury, Jefferson Proaño, Graciela Cárdenas, Marisela ernández, Edda Sciutto, Gladis Fragoso. 2013. Genetic variation in the Cytb gene of human cerebral Taenia solium cysticerci recovered from clinically and radiologically heterogeneous patients with neurocysticercosis., Mem Inst Oswaldo Cruz Vol. 108(7): 914-920. FI. 1.592

25. Diaz-Masmela Y, Fragoso G, Ambrosio JR, Mendoza-Hernández G, Rosas G, Estrada K, Carrero JC, Sciutto E, Laclette JP, Bobes RJ. Immunodiagnosis of porcine cysticercosis: Identification of candidate antigens through immunoproteomics. Vet J. 2013 Sep 30. doi:pii: S1090-0233(13)00484-X. 10.1016/j.tvjl.2013.09.056. FI 1.755

26. Bobes RJ, Fragoso G, Fleury A, García-Varela M, Sciutto E, Larralde C, Laclette JP. Evolution, molecular epidemiology and perspectives on the research of taeniid parasites with special emphasis on Taenia solium. Infect Genet Evol. 2014, 23:150-60. Review. FI. 3.015
27. Navarrete-Perea J, Moguel B, Mendoza-Hernández G, Fragoso G, Sciutto E, Bobes RJ, Laclette JP. Identification and quantification of host proteins in the vesicular fluid of porcine Taenia solium cysticerci. Exp Parasitol. 2014 Aug;143:11-7. FI. 1.638
28. Cárdenas G, Fragoso G, Rosetti M, Uribe-Figueroa L, Rangel-Escareño C, Saenz B, Hernández M, Sciutto E, Fleury A. Neurocysticercosis: the effectiveness of the cysticidal treatment could be influenced by the host immunity. Med Microbiol Immunol. 2014; 203(6):373-81- FI. 3.038
29. Hernández M, Rosas G, Cervantes J, Fragoso G, Rosales-Mendoza S, Sciutto E. Transgenic plants: a 5-year update on oral antipathogen vaccine development. Expert Rev Vaccines. 2014; 13(12):1523-36. FI. 4.2.
30. Elizabeth Monreal-Escalante, Bernardo Bañuelos-Hernánndez, Marisela Hernández, Gladis Fragoso, Teresa Garate, Edda Sciutto, Sergio Rosales-Mendoza. 2015. Expression of Multiple Taenia solium Immunogens in Plant Cells Through a Ribosomal Skip Mechanism. Mol Biotechnol. 2015 Jul;57(7):635-43. FI 1.876
31. Gomez S, Adalid-Peralta L, Palafox-Fonseca H, Cantu-Robles VA, Soberón X, Sciutto E, Fragoso G, Bobes RJ, Laclette JP, Yauner Ldel P, Ochoa-Leyva A. Genome analysis of Excretory/Secretory proteins in Taenia solium reveals their Abundance of Antigenic Regions (AAR). Sci Rep. 2015 May 19;5:9683. FI 5.578

Circuito de Posgrado, Ciudad Universitaria
Alcaldía Coyoacán, C.P. 04510, México, CDMX

55 5623 7006
mdcbq@posgrado.unam.mx