Neuropeptidos: metabolismo en el cerebro y en la articulación neuroendocrina.
La hormona liberadora de tirotropina, su enzima de inactivacion y el control del balance energético.

Publicaciones

99. A. Rodríguez-Rodríguez, I. Lazcano, E. Sánchez-Jaramillo, R.M. Uribe, L. Jaimes-Hoy, P. Joseph-Bravo and J.-L. Charli. Tanycytes and the control of thyrotropin-releasing hormone flux into portal capillaries. Frontiers in Endocrinology, 10: 401 (2019).
100. M. Parra-Montes de Oca, M. Gutiérrez-Mariscal, Ma. F. Salmerón, L. Jaimes-Hoy, J.-L. Charli, and P. Joseph-Bravo. Voluntary exercise-induced activation of thyroid axis and reduction of white fat depots is attenuated by chronic stress in a sex dimorphic pattern in adult rats. Frontiers in Endocrinology, 10: 418 (2019).
101. L. Jaimes-Hoy, F. Romero, J.-L. Charli and P. Joseph-Bravo. Sex dimorphic responses of the hypothalamus-pituitary-thyroid axis to maternal separation and palatable diet. Frontiers in Endocrinology, 19: 445 (2019).
102. I. Pascual Alonso, R. Alonso Bosch, A. Cabrera-Muñoz, W. Perera, and J.-L. Charli, Methanolic extracts of paratoid gland secretion from Cuban Peltophryne toads contain inhibitory activities against peptidases with biomedical relevance. Biotecnología Aplicada, 36: 2221-7 (2019). https://elfosscientiae.cigb.edu.cu/ContenidoIssue.asp?ID=2217
103. P. Joseph-Bravo, I. Lazcano, L. Jaimes-Hoy, M. Gutiérrez-Mariscal, E. Sánchez-Jaramillo, R.M. Uribe, and J.-L. Charli. Sexually dimorphic dynamics of hypothalamus-pituitary-thyroid axis activity during fasting in adult rats. Frontiers in Biosciences, Landmark, 25: 1305-1323 (2020). http://dx.doi.org/10.2741/4857
104. I. Pascual, L. Rivera Méndez, M.E. Valdés Tresanco, L. Bounaadja, M. Schmitt, Y. Arrebola Sánchez, L. Alvarez Lajonchere, J.-L. Charli, and I. Florent. Biochemical evidences for M1-, M17- and M18-like aminopeptidases in marine invertebrates. Zeitschrift für Naturforschung C (2020). https://doi.org/10.1515/znc-2019-0169
105. E. Farkas, E. Varga, B. Kovács, A. Szilvásy-Szabó, A. Cote-Vélez, Z. Péterfi, M. Matziari, M. Tóth, D. Zelena, Z. Mezriczky, A. Kádár, D. Kővári, M. Watanabe, M. Kano, K. Mackie, B. Rózsa, Y. Ruska, B. Tóth, Z. Máté, F. Erdélyi, G. Szabó, B. Gereben, R.M. Lechan, J.-L. Charli, P. Joseph-Bravo, and C. Fekete. A glial-neuronal circuit in the the median eminence regulates thyrotropin-releasing hormone-release via the endocannabinoid system. iScience, 23: 100921 (2020). https://doi.org/10.1016/j.isci.2020.100921
106. J.-L. Charli, A. Rodríguez Rodríguez, K. Hernández, A. Cote-Vélez, R. M. Uribe, L. Jaimes Hoy, and P. Joseph-Bravo. The thyrotropin-releasing hormone-degrading ectoenzyme, a therapeutic target? Frontiers in Pharmacology, 11: 640 (2020). https://doi.org/10.3389/fphar.2020.00640
107. L. Rivera Méndez, Y. Arrebola, M.E. Valdes-Tresanco, L. Díaz-Guevara, G. Bergado, B. Sánchez, J.-L. Charli, and I. Pascual Alonso. Bestatin and bacitracin inhibit porcine kidney cortex dipeptidyl peptidase IV activity and reduce human melanoma MeWo cell viability. International Journal of Biological Macromolecules, 164: 2944-2952 (2020). https://doi.org/10.1016/j.ijbiomac.2020.08.157
108. I. Pascual Alonso, L. Rivera Méndez, F. Almeida, M. E. Valdés Tresanco, Y. Arrebola Sánchez, A. Hernández-Zanuy, L. Álvarez-Lajonchere, D. Díaz, B. Sánchez, I. Florent, M. Schmitt, M. Cisneros, and J. L. Charli. Marine organisms: a source of biomedically relevant M1, M2 and M17 exopeptidase inhibitors. Revista Cubana de Ciencias Biológicas, 8: 1-36 (2020). http://www.rccb.uh.cu/index.php/RCCB/article/view/300
109. I. Pascual Alonso, Y. Arrebola Sánchez, F. Almeida, M. E. Valdés Tresanco, L. Rivera Méndez, A. Hernández-Zanuy, M. Chappé Pacheco, B. Sánchez, J.-L. Charli. Marine and costal organisms: a source of biomedically relevant dipeptidyl peptidase IV inhibitors. Revista Cubana de Ciencias Biológicas, 8: 1-16 (2020). http://www.rccb.uh.cu/index.php/RCCB/article/view/308/365
110. Y. Arrebola, L. Rivera, A. Pedroso, R. McGuire, M.E. Valdes-Tresanco, G. Bergado, J.-L. Charli, B. Sanchez, and I. Pascual. Bacitracin is a non-competitive inhibitor of porcine M1 family neutral and glutamyl aminopeptidases. Natural Product Research 35: 2958–2962 (2021), https://doi.org/10.1080/14786419.2019.1678611.
111. A. Castillo-Campos, A. Gutiérrez-Mata, J.-L. Charli, and P. Joseph-Bravo. Chronic stress inhibits hypothalamus-pituitary-thyroid axis and brown adipose tissue responses to acute cold exposure in male rats. Journal of Endocrinological Investigation 44, 713–723 (2021). https://doi.org/10.1007/s40618-020-01328-z
112. I. Lazcano, A. Rodríguez Rodríguez, R. M. Uribe, A. Orozco, P. Joseph-Bravo, and J.-L. Charli. Evolution of thyrotropin-releasing factor extracellular communication units. General and Comparative Endocrinology, 305, 113642 (2021). https://doi.org/10.1016/j.ygcen.2020.113642
113. L. Jaimes-Hoy, A. Pérez-Maldonado, E. Narváez Bahena, N. de la Cruz Guarneros, A. Rodríguez-Rodríguez, J.-L. Charli, X. Soberón and P. Joseph-Bravo. Sex dimorphic changes in Trh gene methylation and thyroid-axis response to energy demands in maternally-separated rats. Endocrinology, 162, 8, 1-18 (2021). https://doi.org/10.1210/endocr/bqab110
114. M. E. Valdes Tresanco, Y. Arrebola, L. Rivera, F. Almeida, B. Sánchez, J.-L. Charli, and I. Pascual Alonso. Bestatin is a non-competitive inhibitor of porcine M1 family glutamyl aminopeptidase: insights for selective inhibitor design. Indian Journal of Natural Products and Resources, 12, 2, 173-180 (2021). http://nopr.niscair.res.in/handle/123456789/57762
115. I. Pascual Alonso, G. García, L. Díaz, Y. Arrebola, L. Rivera Méndez, F. Almeida García, M. Chappe Pacheco, B. Sánchez, J.-L. Charli. Effect of non-competitive inhibitors of aminopeptidase N on viability of human and murine tumor cells. Pure and Applied Chemistry, (2021). https://doi.org/10.1515/pac-2020-1010
116. M. A. Parra-Montes de Oca, I. Sotelo-Rivera, A. Gutiérrez-Mata, J.-L. Charli, P. Joseph-Bravo. Sex dimorphic responses of the hypothalamus-pituitary-thyroid axis to energy demands and stress. Frontiers in Endocrinology, 12:746924 (2021). https://doi: 10.3389/fendo.2021.746924
117. I. Pascual Alonso, P.A. Valiente, M.E. Valdés-Tresanco, Y. Arrebola, F. Almeida García, L. Díaz, G. García, O. Guirola, D. Pastor, G. Bergado, B. Sánchez, J.-L. Charli. Discovery of tight-binding competitive inhibitors of dipeptidyl peptidase IV. International Journal of Biological Macromolecules, 196, 120-130 (2022). https://doi.org/10.1016/j.ijbiomac.2021.12.056
118. E. Sánchez-Jaramillo, G. Wittmann, J. Menyhért, P. Singru, G.B. Gómez-González, E. Sánchez-Islas, N. Yáñez-Recendis, J.A. Pimentel-Cabrera, M. León-Olea, B. Gereben, C. Fekete, J.-L. Charli, R. M. Lechan. Origin of thyrotropin-releasing hormone neurons that innervate the tuberomammillary nuclei. Brain Structure and Function, https://doi.org/10.1007/s00429-022-02527-5
119. Y. Vargas, M. Parra-Montes de Oca, E. Sanchez-Jaramillo, L. Jaimes-Hoy, E. Sánchez-Islas, R.M. Uribe, P. Joseph-Bravo, and J.-L. Charli. Sex-dependent and -independent regulation of thyrotropin-releasing hormone expression in the hypothalamic dorsomedial nucleus by negative energy balance, exercise, and chronic stress. Brain Research, 1796, 148083 (2022). https://doi.org/10.1016/j.brainres.2022.148083
120. I. Pascual Alonso, L. Rivera Mendez, F. Almeida Garcia, M. E. Valdes-Tresanco, R. Alonso Bosch, W.H. Perera, Y. Arrebola Sánchez, G. Bergado, B. Sanchez Ramírez, J.- L. Charli. Bufadienolides preferentially inhibit aminopeptidase N among mammalian metallo aminopeptidases; relationship with effects on human melanoma MeWo cells. International Journal of Biological Macromolecules, 229, 825-837 (2023). https://doi.org/10.1016/j.ijbiomac.2022.12.280

Circuito de Posgrado, Ciudad Universitaria
Alcaldía Coyoacán, C.P. 04510, México, CDMX

55 5623 7006
mdcbq@posgrado.unam.mx