Mecanismos de control de síntesis de citocinas en las células cebadas.
Transducción de señales en las células cebadas.
Comunicación neuro-inmune en las reacciones inflamatorias.
Inflamación y alergia.

Publicaciones

1. Carranza-Aguilar, C., Hernández-Mendoza, A., Mejias-Aponte, C., Rice, K., Morales, M., González-Espinosa, C., Cruz, S. Morphine and fentanyl repeated administration induces different levels of NLRP3-dependent pyroptosis in the dorsal raphe nucleus of male rats via cell specific activation of TLR4 and opioid receptors. Cellular and Molecular Neurobiology, 2020. Sep 14. doi: 10.1007/s10571-020-00957-5. Índice de impacto 4.58

2. Mutant Huntingtin affects Toll-like receptor 4 intracellular trafficking and cytokine production in mast cells. Pérez-Rodríguez, M.J., Ibarra-Sánchez, A., Román-Figueroa, A., Pérez-Severiano, F., and González-Espinosa, C. Journal of Neuroinflammation 17 : 95, 2020. https://doi.org/10.1186/s12974-020-01758-9. Índice de impacto 5.19

3. Mast cells localize in hypoxic zones of tumors and secrete CCL-2 under hypoxia through activation of L-type calcium channels. Ramírez-Moreno, I.G., Ibarra-Sánchez, A., Castillo-Arellano, J.I., Blank, U., and González-Espinosa, C. The Journal of Immunology, 204(4):1056-1068, 2020. Doi: 10.4049/jimmunol.1801430. Índice de impacto 4.71

3. TLR4 receptor induces 2-AG-dependent tolerance to Lipopolysaccharide and trafficking of CB2 receptor in mast cells. Espinosa-Riquer, Z., Ibarra-Sánchez, A., Vibhushan, S., Bratti, M., Charles, N., Blank, U., Rodríguez-Manzo, G., González-Espinosa, C. The Journal of Immunology, 202 (8):2360-2371, 2019. doi: 10.4049/jimmunol.1800997. Índice de impacto 4.71

4. Chemoinformatic analysis of selected cacalolides from Psacalium decompositum (A. Gray) H. Rob &Brettell and Psaclium peltatum (Kunth) Cass. and their effects of FcεRI-dependent degranulation in mast cells. Castillo-Arellano, J.I., Gómez-Verjan, J. C., Rojano-Vilchis, N.A., Mendoza-Cruz, M., Jiménez-Estrada, M., López-Valdés, H.E., Martínez-Coria, H., Gutiérrez-Juárez, R., González-Espinosa, C., Reyes-Chilpa, R., Arrieta-Cruz, I. Molecules 23:3367; 2018. doi:10.3390/molecules23123367. Índice de impacto 4.55

2.50. HPV-18 E6 oncoprotein and its spliced isoform E6*I regulate the Wnt/bcatenin cell signaling pathway through the TCF-4 transcription factor. Muñoz-Bello, J. O., Olmedo-Nieva, L., Castro-Muñoz, L. J., Contreras-Paredes, A., Manzo-Merino, J., González-Espinosa, C., and Lizano, M. International Journal of Molecular Sciences, 2018. doi: 10.3390/ijms19103153. Índice de impacto 4.55

5. Anandamide inhibits FcεRI-dependent degranulation and cytokine synthesis in mast cells through CB2 and GPR55 receptor activation. Possible involvement of CB2-GPR55 heteromers. Cruz, S.C., Sánchez-Miranda, E., Castillo-Arellano, J. I., Cervantes-Villagrana, R.D., Ibarra-Sánchez, A., and González-Espinosa, C. International Immunopharmacology, 154:344-356, 2018. doi: 10.1016/j.intimp.2018.09.006. Índice de impacto 3.94

6. Tomosyn I functions as a PKCδ-regulated fusion clamp in mast cell degranulation. Madera-Salcedo, I. K., Danelli, L., Tiwari, N. Dema, B., Pacreau, E., Vibhushan, S., Birnbaum, J., Agabriel, C., Liabeuf, V., Klingebiel, C., Menasche, G., Macías-Silva, M., Benhamou, M., Charles, N., González-Espinosa, C., Vitte, J., Blank, U. Science Signaling 2018, Jul 3; 11(537). pii: eaan4350. doi: 10.1126/scisignal.aan4350. Índice de impacto 6.48

7. Jacareubin inhibits FceRI-induced extracellular calcium entry and production of reactive oxygen species required for anaphylactic degranulation in mast cells. Castillo-Arellano, J. I., Guzmán-Gutiérrez, S. L., Ibarra-Sánchez, A., Hernández-Ortega, S., Nieto-Camacho, A., Pedraza-Chaverri, J., Medina Campos, O. N., Reyes-Chilpa, R., González-Espinosa, C. Biochemical Pharmacology, 154: 344-356, 2018. DOI: 10.1016/j.bcp.2018.05.002. Índice de impacto 5.00

8. Stimulation of nAchR7 receptor inhibits TNF synthesis and secretion in response to LPS treatment of mast cells by targeting ERK1/2 and TACE activation. Guzmán-Mejía, F., López-Rubalcava, C., González-Espinosa, C. Journal of Neuroimmune Pharmacology, 13:39-52, 2018. DOI: 10.1007/s11481-017-9760-7. Índice de impacto 3.89

9. Fyn kinase mediates cortical actin ring depolymerization required for mast cell migration inresponse to TGF-β. Ramirez-Valadez, K et al. European Journal of Immunology 47(8):1305-1316, 2017. DOI:10.1002/eji.201646876. Índice de impacto 5.19

9. Kinesin-1 controls mast cell degranulation and anaphylaxis through PI3K-dependent recruitment to the granular Slp3/Rab27b complex. Munoz, I., Danelli, L., Claver, J., Goudin, N., Kurosawa, M., Madera-Salcedo, I. K., Huang, J-D., Fisher, A., González-Espinosa, C., de Saint Basile, G., Blank, U., and Ménasché, G. Journal of Cellular Biology 215(2):203-216, 2016. Factor de impacto 8.81

10. Protein tyrosine kinase Fyn regulates TLR4-elicited responses on mast cells controlling the function of a PP2A/PKCα/β signaling node leading to TNF secretion. Martín-Ávila, A., Medina-Tamayo, J., Ibarra-Sánchez, A., Vázquez-Victorio, G., Castillo-Arellano, J.I., Hernández-Mondragón, A.C., Rivera, J., Madera-Salcedo, I.K., Blank, U., Macías-Silva, M., González-Espinosa, C. J. Immunol 196:5075-5088, 2016. Índice de impacto: 4.71

11. Antihypertensive Properties of a Novel Morphologic derivative (4-tert-buthyl-2,6-bis (thiomorpholine-4-ilmethyl) phenol). Martínez-Aguilar, L., Lezama-Martínez, B.D., Orozco-Cortés, N.V., González-Espinosa, C., Flores Monroy, J., Valencia-Hernández, I. J Cardiovasc Pharmacol 67: 246-251, 2016.

12. GPCRs and Actin-Cytoskeleton Dynamics. Vázquez-Victorio, G., González-Espinosa, C., Espinosa-Riquer, Z., Macías-Silva, M. Methods in Cell Biology. 132: 165-88, 2016.

13. Fyn kinase genetic ablation causes structural abnormalities in mature retina and defective Müller cell function. Chávez-Solano, M., Ibarra-Sánchez, A., Treviño, M., González-Espinosa, C., Lamas, M. Mol Cell Neurosci 72:91-100, 2016.

14. Stress-dependent control of cytokine production in mast cells stimulated through FceRI and Toll-like 4 receptors. Guzmán-Mejía, F., López-Rubalcava, C., González-Espinosa, C. Inflammation and Cell Signaling, 2015. doi: 10.14800/ics.881

15. Vesicular trafficking and signaling for cytokine and chemokine secretion in mast cells. Blank, U., Madera-Salcedo, I., Danelli, L., Claver, J., Tiwari, N., Sánchez-Miranda, E., Vázquez-Victorio, G., Ramírez-Valadez, K.A., Macías-Silva, M., González-Espinosa, C. Front Immunol 5: 453-471, 2014.

Circuito de Posgrado, Ciudad Universitaria
Alcaldía Coyoacán, C.P. 04510, México, CDMX

55 5623 7006
mdcbq@posgrado.unam.mx