Acceso a usuarios
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Tutores

LAURA ALICIA PALOMARES AGUILERA

Instituto de Biotecnología (IBT)

Contacto

Teléfono: 55 56 22 76 71
Email: laura@ibt.unam.mx
Sitio web: Visitar sitio web

Campos de conocimiento

Biofísica
Bioingeniería
Bioquímica
Biotecnología

Líneas de investigación

Bioingeniería del cultivo de células de animales para la producción de glicoproteínas y proteínas multiméricas con uso como medicamentos o vacunas.

Publicaciones

53. Gómez IA, Hernández V, Palomares LA, Ramírez OT* (2018) Flocculation of CHO cells for primary separation of recombinant glycoproteins: Effect on glycosylation profiles. Biochemical Engineering Journal. 132: 244-254.
54. Alcalá AC*, Palomares LA, Ludert JE* (2018) Secretion of the non-structural protein 1 of dengue virus from infected mosquito cells: facts and speculations. Journal of Virology. 92: e00275-18.
55. Espíritu-Ramírez P, Ortega-Balderas NY, Sevilla-Tapia L, Montiel-Martínez AG, Pastor-Flores AR, Palomares LA, Torres-Vega MA* (2018) Gene therapy for treatment of chronic hyperammonemia in a rat model of hepatic encephalopathy. Annals of Hepatology. 17: 1026-1034.
56. Villanueva-Flores F, Miranda-Hernández M, Flores-Flores JO, Porras-Sanjuanico A, Hu H, Pérez-Martínez L, Ramírez OT, Palomares LA* (2019) Poly(vinyl alcohol co-vinyl acetate) as a novel scaffold for mammalian cell culture and controlled drug release. Journal of Materials Science. 54 (10) 7867-7882.
57. Garcia-Garcia WI, Vidal-Limón A, Arrocha-Arcos AA, Palomares LA, Ramírez OT, Miranda-Hernández M* (2019) Rotavirus VP6 protein as a bio-electrochemical scaffold: Molecular dynamics and experimental electrochemistry. Bioelectrochemistry. 127: 180-186.
58. Pastor AR, González-Domínguez G, Ramírez OT, Palomares LA* (2019) Defining the multiplicity and time of infection for the production of Zaire Ebola virus-like particles in the insect cell-baculovirus expression system. Vaccine. 37: 6962-6969.
59. Villanueva-Flores F, Castro-Lugo A, Ramírez OT, Palomares LA* (2020) Understanding cellular interactions with nanomaterials: Towards a rational design of medical nanodevices. Nanotechnology. 31: 132002.
60. Martínez JA, Bulté D, Contreras MA, Palomares LA, Ramírez OT* (2020) Dynamic modeling of CHO cell metabolism using the hybrid cybernetic approach with a novel elementary mode analysis strategy. Frontiers in Bioengineering and Biotechnology. 8: 279. DOI: 10.3389/fbioe.2020.00279.
61. Bulté DB, Palomares LA, Gómez-Parra C, Martínez JA, Contreras MA, Noriega LG, Ramírez OT* (2020) Overexpression of the mitochondrial pyruvate carrier reduces lactate production and increases recombinant protein productivity in CHO cells. Biotechnology and Bioengineering. 117: 2633-2647.
62. Rodríguez M, Castro-Acosta RM, Ruiz-Morales ER, Villanueva-Flores F, Ramírez OT, Palomares LA* (2021) A novel method for the in vitro assembly of virus-like particles and multimeric proteins. Biotechnology Letters. 43 (6): 1155-1161. https://doi.org/10.1007/s10529-021-03093-2.
63. Cuevas-Juarez E, Pando-Robles V, Palomares LA* (2021) Flavivirus vaccines: virus-like particles and single-round infectious particles as promising alternatives. Vaccine. 39 (48): 6990-7000. DOI: 10.1016/j.vaccine.2021.10.049.
64. Palomares LA*, Srivastava IK, Ramírez OT, Cox MMJ (2021) Glycobiology of the insect cell-baculovirus expression system. Adv Biochem Eng Biotechnol. 175: 71-92. DOI: 10.1007/10_2018_61
65. Alcalá AC, Maravillas JL, Meza D, Ramírez OT, Ludert JE, Palomares LA* (2022) Dengue virus NS1 uses the scavenger receptor B1 as a cell receptor in cultured cells. Journal of Virology. 95 (5): e0166421. DOI: 10.1128/JVI.01664-21
66. Villanueva-Flores F*, Palomares LA (2022) Low-cost poly(vinyl formal) for heavy metal removal from water of a polluted river. Water Reuse. 12(1): 52-65. https://doi.org/10.2166/wrd.2022.077.
67. Alcalá AC, Contreras MA, Cuevas-Juárez E, Ramírez OT*, Palomares LA* (2022) Effect of sericin, a silk derived protein, on the amplification of Zika virus in insect and mammalian cell cultures. Journal of Biotechnology. 353: 28-25. https://doi.org/10.1016/j.jbiotec.2022.05.005.
68. Martínez-Barnetche* J, Cortes MC, Castillo CEG, Basto-Abreu A, Lizardi R, Aparicio-Antonio R, López-Martínez I, Cortes-Escamilla A, Ramírez OT, Palomares LA, Barreto-Cabrera D, Rivera-Castro JC, Segura-Sánchez C, Hernández-Ávila M, Barrientos-Gutierrez T, Alpuche-Aranda C (2022) Comparable diagnostic accuracy of SARS-CoV-2 spike RBD and N-specific IgG tests to determine pre-vaccination nation-wise baseline seroprevalence in Mexico. Scientific Reports. 12: 18014.
69. Cruz-Cardenas JA, Gutierrez-Mayret M, López-Arredondo A, Castañeda-Delgado JE, Rojas-Martínez A, Enciso-Moreno JA, Palomares LA, Brunck MEG*. (2022) A pseudotyped lentivirus-based assay to titer SARS-CoV-2 neutralizing antibodies in Mexico. Scientific Reports. 12: 17966.
70. Montiel-Martínez AG, Vargas-Jerónimo RY, Flores-Romero T, Moreno-Muñoiz J, Bravo-Reyna CC, Luqueño-Martínez V, Contreras-Escamilla M, Zamudio-López J, Martínez-Rodríguez s, Barrán-Sánchez F, Villegas-García JC, Barrios-Payán J, Pastor AR, Palomares LA, Esquivel-Guadarrama F, Garrido E, Torres-Vega MA* (2023) Baculovirus-mediated expression of a Helicobacter pylori protein-based multiepitope hybrid gene induces a potent B cell response in mice. Immunobiology. 228: 152334.
71. Cuevas-Juárez E, Liñan-Torres A, Hernández C, Kopylov M, Potter CS, Carragher B, Ramírez OT, Palomares LA* (2023) Mimotope discovery as a tool to design a vaccine against Zika and dengue viruses. Biotechnology and Bioengineering. 120: 2658-2671. doi: 10.1002/bit.28392.
72. Villanueva-Flores F, Pastor A, Palomares LA, Huerta-Saquero A* (2023) A novel formulation of asparaginase encapsulated into virus-like particles of brome mosaic virus: in vitro and in vivo evidence. Pharmaceutics. 15: 2260. doi: 10.3390/pharmaceutics15092260.
73. Pérez-Juárez H, Serrano-Vazquez A, González E, Tojas-Velazquez L, Moran P, Gódinez-Álvarez HO, Hernández E, Portillo T, Ramiro M, Taboada B, Padilla MA, Zaragoza ME, Palomares LA, López S, Alagón A, Arias CF, Xímenez C*. (2023) Longitudinal anti-SARS-CoV-2 antibody immune response in acute and convalescent patients. Frontiers Cellular and Infection Microbiology. 13: 1239700. doi: 10.3389/fcimb.2023.1239700.
74. Guadarrama-Pérez V, Aguilar C, Porras-Sanjuanico A, Merino E, Ramírez OT, Barona-Gomez F, Palomares LA*. Expression in CHO cell cultures of a bacterial biosynthetic pathway producing a small non-ribosomal peptide aldehyde prevents proteolysis of recombinant proteins. Sometido.
Circuito de Posgrado, Ciudad Universitaria
Alcaldía Coyoacán, C.P. 04510, México, CDMX

55 5623 7006
mdcbq@posgrado.unam.mx
UNAM Posgrado