El interés de nuestro laboratorio es investigar los mecanismos que conducen a la muerte neuronal en condiciones que mimetizan la isquemia cerebral y la hipoglucemia.

Publicaciones

1. Quintanar L., Montiel T., Márquez M., González A., Massieu L (2012). Calpain activation is involved in acute manganese neurotoxicity in the rat striatum in vivo. Exp. Neurol 233, 182-192. Indice de impacto 4.6 ISSN 0014-4886
2. Hernández-Fonseca K., Massieu L., García de la Cadena S., Guzmán C., Camacho-Arroyo I (2012). Neuroprotective role of estradiol against neuronal death induced by glucose deprivation in cultured rat hippocampal neurons. Neuroendocrinology, 96, 41-50. Indice de Impacto 3.53 ISSN 00913022 impreso, 1365-2826 electrónico
3. Langurén G., Montiel T., Julio-Amilpas A., Massieu L. (2013). Neuronal damage and cognitive impairment associated with hypoglycemia: an integrated view. Neurochem. Int. 63, 331-343. Indice de Impacto 2.65. ISSN 872-9754
4. Páramo B., Montiel T, Hernández-Espinosa DR. Rivera-Martínez M., Morán J., Massieu L. (2013) Calpain activation induced by glucose deprivation is mediated by oxidative stress and contributes to neuronal damage. Int. J. Biochem. Cell Biol. 45, 2596-2604 Indice de Impacto 4.1 ISSN 1357-2725
5. García de la Cadena S., Hernández-Fonseca K., Camacho-Arroyo I., Massieu L. (2014). Glucose deprivation induces reticulum stress by the PERK pathway and caspase-7- and calpain-mediated caspase-12 activation. Apoptosis, 19, 414-427. Indice de impacto 3.94 ISSN 1360-8185
6. Amador-Alvarado L., Montiel T., Massieu L. (2014). Differential production of reactive oxygen species on distinct brain regions of hypoglycemic mice. Metab. Brain Dis. 29, 711-719. Indice de Impacto 2.2 ISSN: 0885-7490 impreso, ISSN: 1573-7365 electrónico
7. Julio-Amilpas A., Montiel T., Soto-Tinoco E., Gerónimo-Olvera C., Massieu L. (2015). Protection of hypoglycemia-induced neuronal death by beta-hydroxybutyrate involves the preservation of energy levels and decrease production of reactive oxygen species. J Cereb. Blood Flow and Metab. 35, 851-860. Indice de Impacto 5.4 ISSN 0271-678X impreso 1559-7016 electrónico
8. Diaz B, Fuentes-Mera L, Tovar A, Montiel T, Massieu L, Martínez-Rodríguez HG, Camacho A. (2015). Saturated lipids decrease mitofusin 2 leading to endoplasmic reticulum stress activation and insulin resistance in hypothalamic cells. Brain Res. 19, 1627, 80-89. Impacto 2.8 ISSN 0006-8993
9. Camberos-Luna L, Gerónimo-Olvera C, Montiel T., Rincón Heredia R, Massieu L. (2016). The ketone body, β-hydroxybutyrate stimulates the autophagic flux and prevents neuronal death induced by glucose deprivation in cortical cultured neurons. Neuroch. Res. 41, 600-609. Impacto 2.6 ISSN impreso 0364-3190; ISSN electrónico 1573-6903
10. Sandra Gómez-López, Ana Valeria Martínez-Silva, Teresa Montiel, Daniel Osorio-Gómez, Federico Bermúdez-Rattoni, Lourdes Massieu, Diana Escalante-Alcalde. (2016). Neural ablation of the PARK10 candidate Plpp3 leads to dopaminergic transmission deficits without neurodegeneration. Sci Rep. 6, 24028. doi: 10.1038/srep24028. Impacto 5.5 ISSN 2045-2322 impreso 2454-2164 electrónico
11. García de la Cadena S, Massieu L. (2016). Caspases and their role in inflammation and ischemic neuronal death. Focus on caspase-12. Apoptosis, 21, 763-777. Impacto 3.83 ISSN 1360-8185 impreso, 1573675X electrónico
12. Rivero-Segura, NA; Flores-Soto, E; García de la Cadena, S; Coronado-Mares, I; Gomez-Verjan JC.; Ferreira, DG; Cabrera-Reyes, EA.; Lopes, LV, Massieu, L.; Cerbón, M. (2017). Prolactin-induced neuroprotection against glutamate excitotoxicity is mediated by the reduction of [Ca2+]i overload and NF-κB activation. PlosOne doi.org/10.1371/journal.pone.0176910. Impacto 3.5 ISSN 1932-6203
13. Gerónimo- Olvera C, Montiel T, Rincon-Heredia R, Castro-Obregón S, Massieu L. (2017). Autophagy fails to prevent glucose deprivation/glucose reintroduction-induced neuronal death due to calpain-mediated lysosomal dysfunction in cortical neurons. Cell death and Disease. 8, e2911; doi:10.1038/cddis.2017.299; Impacto 6.0 ISSN 2041-4889
14. Languren G, Montiel T, Ramírez-Lugo L, Balderas I, Sánchez-Chávez GSotres-Bayón F, Bermúdez-Rattoni F, Massieu L. (2017). Recurrent moderate hypoglycemia exacerbates oxidative damage and neuronal death leading to cognitive dysfunction after the hypoglycemic coma. J. Cereb. Blood Flow and Metab. DOI: 10.1177/0271678X17733640. Impacto 5.0 ISSN 0271-678X impreso ISSN 1559-7016 electrónico.
15. Nelson‑Mora J, Escobar ML, Rodríguez‑Durán L, Massieu L, Montiel T, Rodríguez VM, Hernández‑Mercado K, Gonsebatt ME. (2017). Gestational exposure to inorganic arsenic (iAs3+) alters glutamate disposition in the mouse hippocampus and ionotropic glutamate receptor expression leading to memory impairment. Arch. Toxicol. doi.org/10.1007/s00204-017-2111-x. Impacto 5.9, ISSN 0340-5761

Circuito de Posgrado, Ciudad Universitaria
Alcaldía Coyoacán, C.P. 04510, México, CDMX

55 5623 7006
mdcbq@posgrado.unam.mx