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Tutores

FERNANDO LÓPEZ CASILLAS

Instituto de Fisiología Celular (IFC)

Contacto

Teléfono: 55 56 22 56 25
Email: fcasilla@ifc.unam.mx
Sitio web: Visitar sitio web

Campos de conocimiento

Biología del Desarrollo
Bioquímica
Genética y Fisiología Celular

Líneas de investigación

Factores de Crecimiento Celular.
Superfamilia del TGF-beta.
Co-receptores del TGF-beta.
Transducion de Señales.
Zebrafish.

Publicaciones

Delolme, F., Anastasi, C., Alcaraz, L.B., Mendoza, V., Vadon-Le Goff, S., Talantikite, M., Capomaccio, R., Mevaere, J., Fortin, L., Mazzocut, D., Damour, O., Zanella-Cleon, I., Hulmes, D.J.S., Overall, C.M., Valcourt, U., López-Casillas, F. and Moali, C. (2015) Proteolytic control of TGF-β co-receptor activity by BMP-1/tolloid-like proteases revealed by quantitative iTRAQ degradomics. Cellular and Molecular Life Sciences 72(5):1009-1027 DOI 10.1007/s00018-014-1733-x.

Kamaid, A., Molina-Villa, T., Mendoza, V., Pujades, C., Maldonado, E., Ispizua-Belmonte, J.C., and López-Casillas, F. (2015) Betaglycan knockdown causes embryonic angiogenesis defects in zebrafish. Genesis, The Journal of Genetics and Development 53:583-603, DOI 10.1002/dvg.22876.

Molina-Villa, T., Mendoza, V., and López-Casillas, F. (2016) Affinity Labeling Detection of Endogenous Receptors from Zebrafish Embryos. J. Vis. Exp. Issue: 114, e54405, doi:10.3791/54405.

Ramos-Espinosa, O., Hernández-Bazán, S., Francisco-Cruz, A., Mata-Espinosa, D., Berrios-Payán, J., Marquina-Castillo, B., López-Casillas, F., Carretero, M., del Rio, M. and Hernández-Pando, R. (2016) Gene therapy based in antimicrobial peptides and proinflammatory cytokine prevents reactivation of experimental latent tuberculosis. Pathogens and Disease 74(7):ftw075, doi:10.1093/femspd/ftw075.

Villareal, M.M., Kim, S.K., Barron, L., Kodali, R., Baardsnes, J., Hinck, C.S., Krzysiak, T.C., Henen, M.A., Pakhomova, O., Mendoza, V., O’Connor-McCourt, M.D., Lafer, E.M., López-Casillas, F. and Hinck, A.P. (2016) Binding properties of the Transforming Growth Factor-β correceptor Betaglycan: proposd mechanism for potentiation of receptor complex assembly and signaling. Biochemistry 55(49):6880-6896.

Arredondo Zamarripa, D., Noguez Imm, R., Bautista Cortés, A.M., Vázquez Ruíz, O., Bernardini, M., Fiorio Pla, A., Gkika, D., Prevarskaya, N., López-Casillas, F., Liedtke, W., Clapp, C. and Thébault, S. (2017) Dual contribution of TRPV4 antagonism in the regulatory effect of vasoinhibins on blood-retinal barrier permeability: diabetic milieu makes a difference. Sci Rep. 7(1):13094. doi: 10.1038/s41598-017-13621-8.

Ortega-Francisco, S., de la Fuente-Granada, M., Alvarez Salazar, E.K., Bolaños-Castro, L.A., Fonseca-Camarillo, G., Olguin-Alor, R., Alemán-Muench, G.R., López-Casillas, F., Raman, C., García-Zepeda, E.A. and Soldevila, G. (2017) TβRIII is induced by TCR signaling and downregulated in FoxP3+ regulatory T cells. Biochem Biophys Res Commun 494(1-2):82-87. doi: 10.1016/j.bbrc.2017.10.081.

Lopez Gonzalez, C., Maldonado Martinez, H.A., Garcia Lopez, S., Rosas Ramirez, M.C., López-Casillas, F., Perez Gonzalez, A. and Gutierrez Valdez, D.H. (2017) Immunoexpression of transforming growth factor-β3 (TGF-β3) and receptor III of β transforming growth factor (TGF β-RIII) in pediatric patients with complete or incomplete non-syndromic cleft palate. Revista Mexicana de Ortodoncia 5(4):210-216.

Melo, Z., Castillo, X., Moreno-Carranza, B., Ledesma-Colunga, M.G., Arnold, E., López-Casillas, F., Ruiz-Herrera, X., Clapp, C. and Martinez de la Escalera, G. (2019) Vasoinhibin Suppresses Nerve Growth Factor-Induced Differentiation and Survival of PC12 Pheochromocytoma Cells. Neuroendocrinology 15:1-13. doi: 10.1159/000499507.

Flores-Cruz, R., López-Arteaga, R., Ramírez-Vidal, L., López-Casillas, F., and Jiménez-Sánchez, A. (2019) Unravelling the Modus-Operandi of Chromenylium-Cyanine Fluorescent Probes: A Case Study. Phys. Chem. Chem. Phys. 21(28):15779-15786, DOI: 10.1039/C9CP03256H.

Kim Kim, S.K., Whitley, M.J., Krzysiak, T.C., Hinck, C.S., Taylor, A.B., Zwieb, C., Byeon, C.-H., Zhou, X., Mendoza, V., López-Casillas, F., Furey, W. and Hinck, A.P. (2019) Structural adaptation in its orphan domain engenders betaglycan with an alternate mode of growth factor binding relative to endoglin. Structure 27:1-16. doi: 10.1016/j.str.2019.06.010

Aroña, R.M., Arnold, E., Macías, F., López-Casillas, F., Clapp, C., Martínez de la Escalera, G. (2020) Vasoinhibin generation and effect on neuronal apoptosis in the hippocampus of late mouse embryos. Phys. Chem. Chem. Phys. Am. J. Physiol. Regul. Integr. Comp. Physiol. 318(4):R760-R771. doi: 10.1152/ajpregu.00286.2019

Neri-Castro, E., Bénard-Valle, M., Paniagua, D., Boyer, L., Possani, L., López-Casillas, F., Olvera, A., Romero, C., Zamudio, F., Alagón, A. (2020) Neotropical Rattlesnake (Crotalus simus) Venom Pharmacokinetics in Lymph and Blood Using an Ovine Model. Toxins (Basel). 12(7):455. doi: 10.3390/toxins12070455.

Molina Molina-Villa, T., Ramirez-Vidal, L., Mendoza, V., Escalante-Alcalde, D. and López-Casillas, F. (2022) Chordacentrum mineralization is delayed in zebrafish betaglycan-null mutants. Developmental Dynamics 251(1):213-225 doi: 10.1002/dvdy.393

Robles Robles, J.P., Zamora, M., Siqueiros‑Marquez, L., Adan‑Castro, E., Ramirez‑Hernandez, G., Freinet N, F., López-Casillas, F., Millar, R.P., Bertsch, T., Martinez de la Escalera, G., Triebel, J. and Clapp, C. (2022) The HGR motif is the antiangiogenic determinant of vasoinhibin: implications for a therapeutic orally active oligopeptide. Angiogenesis 25(1):57-70, DOI 10.1007/s10456-021-09800-x

Bernal-Escalante, J., Molina-Villa, T., López-Casillas, F., and Jiménez-Sánchez, A. (2022) Mitochondria-assisted photooxidation to track singlet oxygen at homeostasyic membrane viscocity. ACS Sensors 26;7(8):2303-2311, DOI: 10.1021/acssensors.2c00933.

Hernández-Bazán, S., Mata-Espinosa, D., Lozano-Ordaz, V., Ramos-Espinosa, O., Barrios-Payán, J., López-Casillas, F. and Hernández-Pando, R. (2022) Immune regulatory effect of osteopontin gene therapy in a murine model of multidrug resistant pulmonary tuberculosis. Human Gene Therapy 33(19-20):1037-1051, doi: 10.1089/hum.2022.030.

Gomez Gomez-Gallegos, A. A., Ramírez-Vidal, L., Becerril-Rico, J., Pérez-Islas, E., Hernandez-Peralta, Z. J., Toledo-Guzmán, M. E., García-Carrancá, A., Langley, E., Hernández-Guerrero, A., López-Casillas, F., Herrera-Goepfert, R., Oñate-Ocaña, L. F. and Ortiz-Sánchez, E. (2023) CD24+CD44+CD54+EpCAM+ gastric cancer stem cells predict tumor progression and metastasis: clinical and experimental evidence. Stem Cell Research & Therapy 33(19-20):1037-1051, doi: 10.1089/hum.2022.030.

Ramirez Ramirez-Vidal, L., Molina-Villa, T., Mendoza, V., Peralta-Alvarez, C. A., Poot-Hernandez, A. C., Dotov, D. and López-Casillas, F. (2023) Betaglycan promoter activity is differentially regulated during myogenesis in zebrafish embryo somites. Developmental Dynamics. doi: 10.1002/dvdy.602. Epub ahead of print. PMID: 37222488.

Circuito de Posgrado, Ciudad Universitaria
Alcaldía Coyoacán, C.P. 04510, México, CDMX

55 5623 7006
mdcbq@posgrado.unam.mx
UNAM Posgrado